Neuropsychological impairment among manic, depressed, and mixed-episode inpatients with bipolar disorder
Neuropsychological impairment among manic, depressed, and mixed-episode inpatients with bipolar disorder
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DOI：
10.1037//0894-4105.16.1.84
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发表时间：
2002-01-01
期刊：
影响因子：
2.4
通讯作者：
Purdie, R
中科院分区：
文献类型：
--
作者：
Basso, MR;Lowery, N;Purdie, R
Z以前的研究已经证明双相情感障碍(参看。G.Cassens，L.Wolfe，&M.Zola，1990)。然而，还没有对躁狂、抑郁或混合亚型患者的神经心理功能进行比较。在本研究中，37名躁狂症患者、24名混合性发作患者和25名抑郁的双相I型患者和34名对照受试者接受了一系列简短的神经心理测试。参与者组对神经心理测试的多变量和单变量效应均为显著(p<；0.05)。有计划的对比显示，双相情感受试者的表现比对照组差，而且3个患者组之间几乎没有差异。此外，在50%的测试电池中，双极基团受损。这些异常不太可能归因于精神症状和内科疾病的差异。共病的精神诊断，或用药情况。研究结果表明，双相情感障碍期间的急性情绪障碍会导致显著的神经行为障碍。
zPrevious research has demonstrated broad neurobehavioral abnormalities in bipolar affective disorder (cf. G. Cassens, L. Wolfe, & M. Zola, 1990). However, there have been no comparisons of neuropsychological function across patients with manic, depressed, or mixed subtypes. In the present Study, 37 manic, 24 mixed-episode, and 25 depressed bipolar I inpatients and 34 control subjects were administered a brief battery of neuropsychological tests. The multivariate and univariate effects of participant group on the neuropsychological measures were uniformly significant (p < .05). Planned contrasts revealed that the bipolar participants performed worse than the controls, and few differences existed between the 3 patient groups. Additionally, the bipolar groups were impaired on 50% of die test battery. These abnormalities were unlikely attributable to differences in psychiatric symptomatology, medical illness. comorbid psychiatric diagnoses, or medication status. Findings imply that acute mood disturbance during bipolar disorder yields significant neurobehavioral dysfunction.