ATLAS OF CATECHOLAMINE PERIKARYA, VARICOSITIES AND PATHWAYS IN THE BRAIN-STEM OF THE CAT
ATLAS OF CATECHOLAMINE PERIKARYA, VARICOSITIES AND PATHWAYS IN THE BRAIN-STEM OF THE CAT
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DOI：
10.1002/cne.902150404
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发表时间：
1983-01-01
影响因子：
2.5
通讯作者：
FRIEDMAN, L
中科院分区：
文献类型：
--
作者：
JONES, BE;FRIEDMAN, L
通过应用改良的乙醛酸-多聚甲醛组织荧光技术，在未处理、预处理或脑内注射6-OHDA [6-羟基多巴胺]的小猫脑干内描绘了儿茶酚胺胞体、静脉曲张和通路。三个主要的儿茶酚胺细胞群被确定在延髓和脑桥;背内侧髓细胞群，背外侧脑桥细胞群和腹外侧细胞群从延髓延伸到脑桥。脑内注射6-OHDA诱导的儿茶酚胺轴突积累揭示了一个主要的纵向儿茶酚胺束，其课程在背外侧位置通过整个脑干被盖。背内侧髓和背外侧脑桥细胞群为该束提供上行和下行纤维。腹外侧脑桥髓质细胞的轴突也通过放射状走行的横纤维在连续的水平上进入纤维束。通过这个主要的背外侧管道及其腹侧和内侧的分支，儿茶酚胺纤维和终末分布到脑干的多个核团。儿茶酚胺细胞群的区域和5-羟色胺[5-羟色胺，5-H]中缝核都接受密集的儿茶酚胺神经支配。静脉曲张在内脏脑神经核中也是致密的，在大多数躯体脊髓和脑神经运动核中是中等密度的，在感觉脑神经和中继核中是中等至轻度的。外侧和腹内侧网状结构由穿过这些区域的静脉曲张的儿茶酚胺纤维适度支配。纵向的儿茶酚胺束继续向尾侧进入外侧索，下降进入并支配脊髓。在吻侧，它继续进入中脑的被盖束，上升进入间脑并支配间脑，在那里加入内侧前脑束，上升进入端脑。儿茶酚胺神经元利用该背外侧纵束将侧支分布到多个球核，并行进到脑干之外以神经支配脊髓和前脑。
By application of a modified glyoxylic acid-paraformaldehyde histofluorescence technique, catecholamine perikarya, varicosities and pathways were delineated within the brainstem of kittens that were either untreated, pretreated pharmacologically, or injected intracerebrally with 6-OHDA [6-hydroxydopamine]. Three principal catecholamine cell groups were identified within the medulla and pons; the dorsomedial medullary cell group, the dorsolateral pontine cell group and a ventrolateral cell group extending from the medulla into the pons. Induced axonal accumulation of catecholamines with intracerebral 6-OHDA injections revealed a major longitudinal catecholamine bundle which courses in a dorsolateral position through the entire brainstem tegmentum. The dorsomedial medullary and dorsolateral pontine cell groups contribute ascending and descending fibers to this bundle. Axons of the ventrolateral pontomedullary cells also feed into the bundle at successive levels through radially coursing transverse fibers. Via this major dorsolateral conduit and its ventrally and medially coursing tributaries, catecholamine fibers and terminals are distributed to multiple nuclei through the brainstem. The regions of the catecholamine cell groups and the serotonin [5-hydroxytryptamine, 5-H] raphe nuclei all receive a dense catecholamine innervation. Varicosities are also dense in the visceral cranial nerve nuclei, moderately dense in most somatic spinal and cranial nerve motor nuclei and moderate to light in sensory cranial nerve and relay nuclei. The lateral and ventromedial reticular formation are moderately innervated by varicose catecholamine fibers that traverse these regions. The longitudinal catecholamine bundle continues caudally into the lateral funiculus to descend into and innervate the spinal cord. Rostrally it continues into the tegmental fascicles of the midbrain to ascend into and innervate the diencephalon and there join the medial forebrain bundle to ascend into the telencephalon. The catecholamine neurons utilize this dorsolateral longitudinal bundle to distribute collaterals to multiple bulbar nuclei and to travel beyond the brainstem to innervate the spinal cord and forebrain.