Effect of omega-3 fatty acids on heart rate variability in depressed patients with coronary heart disease.
Effect of omega-3 fatty acids on heart rate variability in depressed patients with coronary heart disease.
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DOI：
10.1097/psy.0b013e3181eff148
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发表时间：
2010-10
影响因子：
3.3
通讯作者：
Rich MW
中科院分区：
文献类型：
--
作者：
Carney RM;Freedland KE;Stein PK;Steinmeyer BC;Harris WS;Rubin EH;Krone RJ;Rich MW
omega-3 脂肪酸 (FA) 摄入量低与抑郁症和心率变异性 (HRV) 低有关，这三者都与冠心病 (CHD) 患者死亡风险增加有关。本研究的目的是确定 omega-3 FA 是否会增加甚低频 (lnVLF) 功率（HRV 指数）的自然对数，并降低患有先心病 (CHD) 的抑郁患者的 24 小时心率 (HR)。 36 名患有 CHD 的抑郁症患者随机接受每天 50 毫克舍曲林和 2 克 omega-3 治疗，36 名随机接受舍曲林和安慰剂治疗，在基线和治疗 10 周后测量 24 小时 HRV。协变量调整的 lnVLF (p = 0.009)、平均 24 小时 HR (p = 0.03) 和一分钟静息 HR (p = 0.02) 存在显着的治疗 X 时间交互作用。对于 HRV 的其他三项测量，交互作用并不显着。 omega-3 组中的 LnVLF 没有随时间变化，但安慰剂组中 LnVLF 有所下降 (p = 0.002)，表明 omega-3 可能预防或减缓了心脏自主功能的恶化。 omega-3 FA 对 lnVLF 和 HR 的影响虽然不大，但仅在每天 2 克 omega-3 治疗十周后就被检测到。较长疗程或较高剂量的 omega-3 是否会进一步降低 HR、改善 HRV 的其他指标或降低抑郁性 CHD 患者的死亡率，值得研究。
Low intake of omega-3 fatty acids (FAs) is associated with depression and with low heart rate variability (HRV), and all three are associated with an increased risk of death in patients with coronary heart disease (CHD). The purpose of this study was to determine whether omega-3 FA increases the natural log of Very Low Frequency (lnVLF) power, an index of HRV, and reduces 24 hour heart rate (HR) in depressed patients with CHD. Thirty-six depressed patients with CHD randomized to receive 50 mgs of sertraline and two grams of omega-3/day, and 36 randomized to sertraline and a placebo, had 24 hour HRV measured at baseline and following 10 weeks of treatment. There was a significant treatment X time interaction for covariate adjusted lnVLF (p=0.009), for mean 24 hour HR (p = 0.03), and for one minute resting HR (p = 0.02). The interaction was not significant for three other measures of HRV. LnVLF did not change over time in the omega-3 arm, but decreased in the placebo arm (p= 0.002), suggesting that omega-3 may have prevented or slowed deterioration in cardiac autonomic function. The effects of omega-3 FAs on lnVLF and HR, although modest, were detected after only ten weeks of treatment with two grams per day of omega-3. Whether a longer course of treatment or a higher dose of omega-3 would further decrease HR, improve other indices of HRV, or reduce mortality in depressed CHD patients, should be investigated.