Apolipoprotein A-I, elevated in trauma patients, inhibits platelet activation and decreases clot strength.
Apolipoprotein A-I, elevated in trauma patients, inhibits platelet activation and decreases clot strength.
复制标题
DOI：
10.1080/09537104.2022.2078488
复制
发表时间：
2022-11-17
期刊：
影响因子：
3.3
通讯作者：
中科院分区：
文献类型：
--
作者：
Apolipoprotein A-I (ApoA-I) is elevated in the plasma of a subgroup of trauma patients with systemic hyperfibrinolysis. We hypothesize that apoA-I inhibits platelet activation and clot formation. The effects of apoA-I on human platelet activation and clot formation were assessed by whole blood thrombelastography (TEG), platelet aggregometry, P-selectin surface expression, microfluidic adhesion, and Akt phosphorylation. Mouse models of carotid artery thrombosis and pulmonary embolism were used to assess the effects of apoA-I in vivo. The ApoA-1 receptor was investigated with transgenic mice knockouts (KO) for the scavenger receptor class B member 1 (SR-BI). Compared to controls, exogenous human apoA-I inhibited arachidonic acid and collagen-mediated human and mouse platelet aggregation, decreased P-selectin surface expression and Akt activation, resulting in diminished clot strength and increased clot lysis by TEG. ApoA-I also decreased platelet aggregate size formed on a collagen surface under flow. In vivo, apoA-I delayed vessel occlusion in an arterial thrombosis model and conferred a survival advantage in a pulmonary embolism model. SR-BI KO mice significantly reduced apoA-I inhibition of platelet aggregation versus wild type platelets. Exogenous human apoA-I inhibits platelet activation, decreases clot strength and stability, and protects mice from arterial and venous thrombosis via the SR-BI receptor.
登录
查看更多内容
DOI：
10.1097/ta.0b013e318169cd3c
发表时间：
2008-05-01
影响因子：
--
作者：
Brohi, Karim;Cohen, Mitchell J.;Pittet, Jean-Francois
通讯作者：
Pittet, Jean-Francois
影响因子：
37.8
作者：
Calkin, Anna C.;Drew, Brian G.;Jackson, Shaun P.
通讯作者：
Jackson, Shaun P.
DOI：
10.1111/jth.13875
发表时间：
2018-03
期刊：
Journal of thrombosis and haemostasis : JTH
影响因子：
--
作者：
Branchford BR;Stalker TJ;Law L;Acevedo G;Sather S;Brzezinski C;Wilson KM;Minson K;Lee-Sherick AB;Davizon-Castillo P;Ng C;Zhang W;Neeves KB;Lentz SR;Wang X;Frye SV;Shelton Earp H 3rd;DeRyckere D;Brass LF;Graham DK;Di Paola JA
通讯作者：
Di Paola JA
影响因子：
3.4
作者：
Chapman, Michael P.;Moore, Ernest E.;Sauaia, Angela
通讯作者：
Sauaia, Angela
影响因子：
37.8
作者：
Barrett, Tessa J.;Distel, Emilie;Fisher, Edward A.
通讯作者：
Fisher, Edward A.