Male gender and kidney illness associated with an increased risk of severe laboratory-confirmed coronavirus disease
Male gender and kidney illness associated with an increased risk of severe laboratory-confirmed coronavirus disease
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男性和肾脏疾病与实验室确诊的严重冠状病毒病风险增加相关
DOI：
10.1101/2020.06.29.20142562
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发表时间：
2020
期刊：
影响因子：
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通讯作者：
O. Mendoza
中科院分区：
文献类型：
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作者：
E. Murillo;X. Trujillo;M. Huerta;M. Ríos;O. Mendoza
目的：探讨实验室阳性（定量逆转录聚合酶链反应）感染的青少年和成人重症冠状病毒病2019 （COVID-19）的预测因素。方法：进行回顾性队列研究，分析来自墨西哥所有32个州的740名受试者的数据。通过风险比（rr）和95%置信区间（ci）评估研究因素与严重（需要住院的呼吸困难）COVID-19之间的相关性。结果：28%的参与者患有严重疾病。在多个分析,男性性别(RR = 1.13, 95%置信区间1.06 - 1.20),高龄([参考15 - 29岁):30 - 44岁,RR = 1.02, 95%可信区间0.94 - 1.11;45 - 59岁,RR = 1.26, 95%可信区间1.15 - 1.38;60岁或以上,RR = 1.44, 95%置信区间1.29 - 1.60),慢性肾脏疾病(RR = 1.31, 95% CI 1.04 - 1.64)和胸疼痛(RR = 1.16, 95% CI 1.10 - 1.24)与严重疾病的风险增加有关。结论：据我们所知，这是首个在拉丁美洲大量人口中评估COVID-19严重程度预测因素的研究。这也是第一次记录与疾病严重程度有关的性别差异。这些结果可能有助于制定早期发现和管理COVID-19患者的卫生保健方案，这些方案可能受益于及时和专门的支持性医疗。
Objective: To identify factors predicting severe coronavirus disease 2019 (COVID-19) in adolescent and adult patients with laboratory-positive (quantitative reverse-transcription polymerase chain reaction) infection. Methods: A retrospective cohort study took place, and data from 740 subjects, from all 32 states of Mexico, were analyzed. The association between the studied factors and severe (dyspnea requiring hospital admission) COVID-19 was evaluated through risk ratios (RRs) and 95% confidence intervals (CIs). Results: Severe illness was documented in 28% of participants. In multiple analysis, male gender (RR = 1.13, 95% CI 1.06 - 1.20), advanced age ([reference: 15 - 29 years old] 30 - 44, RR = 1.02, 95% CI 0.94 - 1.11; 45 - 59, RR = 1.26, 95% CI 1.15 - 1.38; 60 years or older, RR = 1.44, 95% CI 1.29 - 1.60), chronic kidney disease (RR = 1.31, 95% CI 1.04 - 1.64) and thoracic pain (RR = 1.16, 95% CI 1.10 - 1.24) were associated with an increased risk of severe disease. Conclusions: To the best of our knowledge, this is the first study evaluating predictors of COVID-19 severity in a large subset of the Latin-American population. It is also the first in documenting gender-related differences regarding the severity of the illness. These results may be useful for health care protocols for the early detection and management of COVID-19 patients that may benefit from opportune and specialized supportive medical treatment.