Leptin and adiponectin: Distribution and associations with cardiovascular risk factors in men and women of the general population
Leptin and adiponectin: Distribution and associations with cardiovascular risk factors in men and women of the general population
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DOI：
10.1002/ajhb.22279
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发表时间：
2012-09-01
影响因子：
2.9
通讯作者：
Brismar, Kerstin
中科院分区：
文献类型：
--
作者：
Andreasson, Anna Nixon;Unden, Anna-Lena;Brismar, Kerstin
目的：鉴于肥胖症在全球范围内的患病率不断上升，了解最近发现的脂肪因子瘦素和脂联素的作用具有很高的临床意义。本研究的目的是评估瘦素和脂联素水平与年龄、已知心血管危险因素之间的关系，并确定普通人群中男性和女性之间是否存在差异。方法：选取20 ~ 74岁的普通人群，男性98人，女性107人，在某临床研究中心接受医学检查，并采集空腹晨血。结果：女性瘦素（男性平均7.5 μ g -1，女性平均16.0 μ g -1）和脂联素（男性平均7.3 mg -1，女性平均11.9 mg -1）水平高于男性（p < 0.001）。瘦素和脂联素水平随年龄增长而升高（p < 0.05）。在男性中，瘦素与代谢综合征因素高度相关，而在女性中，瘦素与炎症因素高度相关。脂联素与男性和女性的血脂有关，女性的葡萄糖稳态比男性更多。结论：女性瘦素和脂联素水平分别是男性的2倍和1.5倍。此外，尽管瘦素和脂联素在男性和女性中都与CVD危险因素相关，但我们观察到特定CVD危险因素组在男性和女性之间存在差异。这些差异可能是由于这些脂肪因子在男性和女性中的调节机制和作用不同。点。j .的嗡嗡声。医学杂志。, 2012年。(c) 2012 Wiley期刊有限公司
Objective: In view of the increasing prevalence of obesity worldwide, understanding the role of the recently discovered adipokines leptin and adiponectin is of high clinical relevance. The aim of the present study was to assess the association between levels of leptin and adiponectin with age, known cardiovascular risk factors and to establish whether there are differences between men and women of the general population. Methods: A total of 98 men and 107 women of the general population, aged between 20 and 74 years, underwent a medical examination at a clinical research center and fasting morning blood samples were also taken. Results: Leptin (mean 7.5 mu g l-1 in men and 16.0 mu g l-1 in women) and adiponectin (mean 7.3 mg l-1 in men and 11.9 mg l-1 in women) levels were higher in women than men (Ps < 0.001). Both leptin and adiponectin levels increased with advancing age in both men and women (Ps < 0.05). Leptin was highly associated with factors for metabolic syndrome in men while in women, leptin was highly associated with inflammatory factors. Adiponectin was associated with blood lipids in both men and women, and glucose homeostasis more in women than in men. Conclusions: Leptin and adiponectin levels were 2 times and 1.5 times higher in women than in men, respectively. In addition, although leptin and adiponectin were associated to CVD risk factors in both men and women, we observed differences in specific CVD risk factor groups between men and women. These differences may be due to different regulatory mechanisms and effects of these adipokines in men and women. Am. J. Hum. Biol., 2012. (c) 2012 Wiley Periodicals, Inc.