Unraveling the mystery of HLA-B27 association with human spondyloarthropathies using transgenic and knock out mice.
Unraveling the mystery of HLA-B27 association with human spondyloarthropathies using transgenic and knock out mice.
复制标题
使用转基因和基因敲除小鼠揭开 HLA-B27 与人类脊柱关节病关联的神秘面纱。
DOI：
10.1006/smim.1997.0101
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
David,CS
中科院分区：
文献类型：
--
作者：
Khare,SD;Luthra,HS;David,CS
Human spondyloarthropathies have a strong association with the presence of MHC class I allele, HLA-B27. Spondyloarthropathies occur predominantly in males and are usually triggered by an infection with an enterobacteria. Similar to human disease, experimental animals with HLA-B27 transgene also develop spontaneous inflammatory disease. In addition to HLA-B27, the role of environmental antigens has also been implicated in the animal models. How bacteria interact with HLA-B27 is not yet clearly understood. By breeding HLA-B27 transgenic mice with various transgenic and knock out mice, we investigated the immune mechanism in this inflammatory disease. In this review, we will summarize our recent findings and propose a hypothesis.
