Rheumatoid Factor Is Associated With the Distribution of Hand Joint Destruction in Rheumatoid Arthritis.
Rheumatoid Factor Is Associated With the Distribution of Hand Joint Destruction in Rheumatoid Arthritis.
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DOI：
10.1002/art.39306
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发表时间：
2015-12
期刊：
影响因子：
--
通讯作者：
Matsuda F
中科院分区：
文献类型：
--
作者：
Terao C;Yamakawa N;Yano K;Markusse IM;Ikari K;Yoshida S;Furu M;Hashimoto M;Ito H;Fujii T;Ohmura K;Murakami K;Takahashi M;Hamaguchi M;Tabara Y;Taniguchi A;Momohara S;Raychaudhuri S;Allaart CF;Yamanaka H;Mimori T;Matsuda F
类风湿性关节炎（RA）是一种导致关节破坏的慢性疾病。虽然许多研究已经解决了与关节破坏速度潜在相关的因素，但较少关注RA患者关节破坏的分布。本研究将类风湿性关节炎患者手部骨骼破坏分为手指和非手指两个解剖亚组，旨在分析哪些因素与手指关节破坏相关。从2个不同人群中共招募了1，215例日本RA患者。采用改良Sharp/货车der Heijde评分（SHS）评价关节破坏程度。以指关节损伤的SHS评分为因变量，以非指关节损伤的SHS评分为协变量。年龄、性别、病程、吸烟、C-反应蛋白水平、RA治疗、抗瓜氨酸蛋白抗体和类风湿因子（RF）的阳性率和水平作为候选相关因素进行评价。在荟萃分析中评估了总体效应量。此外，将在日本患者中观察到的相关性与BeSt研究（一项随机对照试验，涉及4种不同的严格规定的早期RA治疗策略）中157例荷兰RA患者的相关性进行了比较。毫不奇怪，日本RA患者的病程与手指SHS评分相关（P ≤ 0.00037）。校正协变量后，RF的阳性率和水平均与手指SHS评分显著相关（分别为P = 0.0022和P = 8.1 × 10−7）。这些协会也是真实的时间平均手指SHS评分。在BeSt研究中，在荷兰RA患者中也观察到RF阳性与手指SHS评分之间的相关性（P = 0.049）。RF阳性和水平与指关节破坏相关，独立于非指关节破坏和其他协变量。我们的研究结果表明，有不同的机制，关节破坏操作在手指关节类风湿关节炎患者。
Rheumatoid arthritis (RA) is a chronic disease leading to joint destruction. Although many studies have addressed factors potentially correlated with the speed of joint destruction, less attention has been paid to the distribution of joint destruction in patients with RA. In this study, destruction of the hand bones in patients with RA was classified into 2 anatomic subgroups, the fingers and the non-fingers, with the aim of analyzing which factors are associated with destruction of the finger joints. A total of 1,215 Japanese patients with RA were recruited from 2 different populations. The degree of joint destruction was assessed using the total modified Sharp/van der Heijde score (SHS) of radiographic joint damage. The SHS score of joint damage in the finger joints was used as the dependent variable, and the SHS score in the non-finger joints was used as a covariate. Age, sex, disease duration, smoking, C-reactive protein level, treatment for RA, and positivity for and levels of anti–citrullinated protein antibodies and rheumatoid factor (RF) were evaluated as candidate correlates. Overall effect sizes were assessed in a meta-analysis. In addition, associations observed in the Japanese patients were compared to those in a cohort of 157 Dutch RA patients in the BeSt study (a randomized, controlled trial involving 4 different strictly specified treatment strategies for early RA). Not surprisingly, disease duration in Japanese patients with RA was associated with the finger SHS score (P ≤ 0.00037). Both positivity for and levels of RF showed significant associations with the finger SHS score after adjustment for covariates (P = 0.0022 and P = 8.1 × 10−7, respectively). These associations were also true in relation to the time-averaged finger SHS score. An association between RF positivity and the finger SHS score was also observed in Dutch patients with RA in the BeSt study (P = 0.049). Positivity for and levels of RF are associated with finger joint destruction independent of non-finger joint destruction and other covariates. Our findings suggest that there are different mechanisms of joint destruction operating in the finger joints of patients with RA.
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影响因子：
9.8
作者：
Han, Buhm;Diogo, Dorothee;Raychaudhuri, Soumya
通讯作者：
Raychaudhuri, Soumya
影响因子：
3.7
作者：
Terao C;Ohmura K;Ikari K;Kochi Y;Maruya E;Katayama M;Yurugi K;Shimada K;Murasawa A;Honjo S;Takasugi K;Matsuo K;Tajima K;Suzuki A;Yamamoto K;Momohara S;Yamanaka H;Yamada R;Saji H;Matsuda F;Mimori T
通讯作者：
Mimori T
影响因子：
--
作者：
Goekoop-Ruiterman, YPM;de Vries-Bouwstra, JK;Dijkmans, C
通讯作者：
Dijkmans, C
影响因子：
2.2
作者：
Hashiramoto, Akira;Shiozawa, Kazuko;Shiozawa, Shunichi
通讯作者：
Shiozawa, Shunichi
影响因子：
--
作者：
SHARP, JT;BLUHM, GB;YOUNG, DY
通讯作者：
YOUNG, DY