Influence of prenatal ethanol exposure on hormonal responses to clonidine and naloxone in prepubescent male and female rats.
Influence of prenatal ethanol exposure on hormonal responses to clonidine and naloxone in prepubescent male and female rats.
复制标题
产前乙醇暴露对青春期前雄性和雌性大鼠对可乐定和纳洛酮激素反应的影响。
DOI：
10.1016/0306-4530(86)90036-3
复制
发表时间：
1986
影响因子：
3.7
通讯作者：
Lane,LA
中科院分区：
文献类型：
--
作者：
McGivern,RF;Poland,RE;Noble,EP;Lane,LA
在出生前接触酒精后，成年动物的性二型性行为的表达被发现发生了变化。本研究检测了在正常青春期前动物中观察到的这种暴露是否会改变黄体生成素对可乐定和纳洛酮的性二型反应。在16日龄雄性和雌性大鼠分别注射纳洛酮(2 mg/kg)和可乐定(0.1 mg/kg)30min后，测定黄体生成素和皮质酮。孕期酒精暴露不会影响女性对任何一种药物的黄体生成素反应。在正常男性中没有发生对可乐定的促黄体生成素反应，但在子宫内暴露于酒精的男性和配对喂养的对照组中出现了这种反应。产前酒精暴露影响CS对两种药物的反应。与注射生理盐水的男性相比，接受纳洛酮治疗的产前暴露于酒精的男性的CS水平降低。其他组注射纳洛酮后CS水平与注射生理盐水相比无明显变化。在可乐定作用下，两性正常动物的CS水平均有升高。然而，可乐定对孕期接触酒精的雌性和雄性动物的CS释放都没有这种刺激作用。本研究结果表明，胎儿期酒精暴露可能改变幼年动物去甲肾上腺素和阿片类药物对皮质酮和黄体生成素的调节。
The expression of sexually dimorphic behavior has been found to be altered in adult animals following prenatal alchohol exposure. The present study examined whether such exposure would alter the sexually dimorphic response of luteinizing hormone (LH) to clonidine and naloxone observed in normal prepubescent animals. Both LH and corticosterone (CS) were measured in 16 day old male and female rats 30 min after injection of naloxone (2 mg/kg) or clonidine (0.1 mg/kg). Prenatal alcohol exposure did not influence the LH response to either drug in females. An LH response to clonidine in normal males did not occur, but it was present in the males exposed to alcohol in utero and in the pair-fed controls. Prenatal alcohol exposure influenced the CS response to both drugs. CS levels were depressed in the naloxone-treated males prenatally exposed to alcohol compared to their saline-injected counterparts. The CS levels of other groups following naloxone administration were unchanged compared to saline injection. Normal animals of both sexes exhibited an elevation in CS levels following clonidine. However, this stimulatory effect of clonidine on CS release was absent in both female and male animals prenatally exposed to alcohol. The results of this study indicate that prenatal alcohol exposure may alter noradrenergic and opioid modulation of corticosterone and possibly of LH in young animals.