Nontarget Screening with High Resolution Mass Spectrometry in the Environment: Ready to Go?
Nontarget Screening with High Resolution Mass Spectrometry in the Environment: Ready to Go?
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DOI：
10.1021/acs.est.7b02184
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发表时间：
2017-10-17
影响因子：
11.4
通讯作者：
Ferguson, P. Lee
中科院分区：
文献类型：
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作者：
Hollender, Juliane;Schymanski, Emma L.;Ferguson, P. Lee
有机污染物种类繁多、差异巨大，这对环境科学、工程学和监管而言是一项严峻挑战。基于高分辨率质谱（HRMS）的非靶向筛查（NTS）在帮助描述这一复杂领域方面具有巨大潜力，但它是否已准备好应用于实际呢？在这篇专题文章中，我们认为，随着质谱仪分辨率不断提高以及与液相色谱和气相色谱新型联用技术的发展，再加上高性能计算的整合，我们的分析范围已显著扩大，并且能够采用日益复杂的数据处理策略，这表明NTS前景光明。如莱茵河实时污染物监测案例所强调的，NTS在监管应用中对于处理评估和污染物优先级排序具有巨大潜力。我们讨论了未来面临的挑战，包括从研究向以解决方案为中心、稳健且协调一致的应用过渡。
The vast, diverse universe of organic pollutants is a formidable challenge for environmental sciences, engineering, and regulation. Nontarget screening (NTS) based on high resolution mass spectrometry (HRMS) has enormous potential to help characterize this universe, but is it ready to go for real world applications? In this Feature article we argue that development of mass spectrometers with increasingly high resolution and novel couplings to both liquid and gas chromatography, combined with the integration of high performance computing, have significantly widened our analytical window and have enabled increasingly sophisticated data processing strategies, indicating a bright future for NTS. NTS has great potential for treatment assessment and pollutant prioritization within regulatory applications, as highlighted here by the case of real-time pollutant monitoring on the River Rhine. We discuss challenges for the future, including the transition from research toward solution centered and robust, harmonized applications.