Circular RNA hsa_circ_0085131 is involved in cisplatin-resistance of non-small-cell lung cancer cells by regulating autophagy
Circular RNA hsa_circ_0085131 is involved in cisplatin-resistance of non-small-cell lung cancer cells by regulating autophagy
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DOI：
10.1002/cbin.11401
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发表时间：
2020-06-19
影响因子：
3.9
通讯作者：
Kong, Rui
中科院分区：
文献类型：
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作者：
Kong, Rui
非小细胞肺癌（NSCLC）继续高居全球癌症死亡率榜首。环状rna （circRNAs）在肿瘤发生中的作用越来越受到重视，尽管它在非小细胞肺癌中的研究相对较少。本文中，我们报道了hsa_circ_0085131在NSCLC中的作用。在本研究中，NSCLC肿瘤标本中hsa_circ_0085131水平高于肿瘤旁标本。高水平的hsa_circ_0085131与NSCLC的复发和较差的生存率相关。此外，hsa_circ_0085131促进细胞增殖和顺铂（DDP）耐药。此外，hsa_circ_0085131通过调节自噬来调节细胞对ddp的抗性。Hsa_circ_0085131作为miR-654-5p的竞争内源性RNA，释放自噬相关因子ATG7的表达，从而促进细胞化疗耐药。综上所述，hsa_circ_0085131通过分离miR-654-5p上调ATG7，从而增强NSCLC细胞对ddp的抗性，导致细胞自噬。因此，这些发现提倡靶向hsa_circ_0085131/miR-654-5p/ATG7轴作为对DDP耐药的NSCLC患者的潜在治疗选择。
Non-small-cell lung carcinoma (NSCLC) continues to top the list of cancer mortalities worldwide. The role of circular RNAs (circRNAs) in tumorigenesis has been increasingly appreciated, although it is relatively unexplored in NSCLC. Herein, we reported the role of hsa_circ_0085131 in NSCLC. In the present study, NSCLC tumor specimens exhibited a higher hsa_circ_0085131 level in comparison to para-tumor samples. And the higher level of hsa_circ_0085131 was associated with recurrence and poorer survival of NSCLC. Moreover, hsa_circ_0085131 promoted cell proliferation and cisplatin (DDP)-resistance. Furthermore, hsa_circ_0085131 regulated cell DDP-resistance by modulating autophagy. Hsa_circ_0085131 acted as a competing endogenous RNA of miR-654-5p to release autophagy-associated factor ATG7 expression, thereby promoting cell chemoresistance. In conclusion, hsa_circ_0085131 enhances DDP-resistance of NSCLC cells through sequestering miR-654-5p to upregulate ATG7, leading to cell autophagy. Therefore, these findings advocate targeting the hsa_circ_0085131/miR-654-5p/ATG7 axis as a potential therapeutic option for patients with NSCLC who are resistant to DDP.