Element Mapping in Organic Samples Utilizing a Benchtop X-Ray Fluorescence Emission Tomography (XFET) System.
Element Mapping in Organic Samples Utilizing a Benchtop X-Ray Fluorescence Emission Tomography (XFET) System.
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DOI：
10.1109/tns.2015.2465380
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发表时间：
2015-10
影响因子：
1.8
通讯作者：
Meng LJ
中科院分区：
文献类型：
--
作者：
Groll A;George J;Vargas P;La Rivière PJ;Meng LJ
X射线荧光计算机断层扫描（XFCT）是一种新兴的成像方式，它映射的三维分布的元素，通常是金属，在离体标本和潜在的活动物和人类。在我们以前的同步加速器为基础的工作的基础上，我们实验性地探索了使用台式X射线荧光计算机断层扫描系统来映射生物样品中的痕量金属离子。该系统利用扫描光束激发物体，然后依靠探测系统，在位置敏感X射线探测器的前面放置单个或多个狭缝孔径，以收集荧光X射线并形成3-D元素图，而不需要层析成像重建。该技术被用来生成图像的元素分布的三管幻影和锇染色的斑马鱼。
X-ray fluorescence computed tomography (XFCT) is an emerging imaging modality that maps the three-dimensional distribution of elements, generally metals, in ex vivo specimens and potentially in living animals and humans. Building on our previous synchrotron-based work, we experimentally explored the use of a benchtop X-ray fluorescence computed tomography system for mapping trace-metal ions in biological samples. This system utilizes a scanning pencil-beam to stimulate the object and then relies on a detection system, with single or multiple slit apertures placed in front of position-sensitive X-ray detectors, to collect the fluorescence X-rays and to form 3-D elemental map without the need for tomographic imaging reconstruction. The technique was used to generate images of the elemental distributions of a triple-tube phantom and an osmium-stained zebrafish.