Russell bodies: a light and electron microscopic immunoperoxidase study.
Russell bodies: a light and electron microscopic immunoperoxidase study.
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罗素体：光学和电子显微镜免疫过氧化物酶研究。
DOI：
10.1093/ajcp/77.1.26
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发表时间：
1982
影响因子：
3.5
通讯作者：
Herbert Fanger
中科院分区：
文献类型：
--
作者：
Su;Pei;Paul N. McMillan;Herbert Fanger
罗素体以前被认为是免疫球蛋白的聚集体。光镜和电子显微镜免疫过氧化物酶研究表明，罗素体核心中没有可检测到的免疫球蛋白决定簇。组织制备过程中抗原变性似乎是一个不太可能的解释，因为浆细胞胞质中的免疫球蛋白被清楚地证明。细胞内小罗素体表面存在免疫球蛋白可能代表周围粗面内质网中的免疫球蛋白决定簇。罗素体似乎含有非免疫球蛋白分子、免疫球蛋白合成的副产物或一些不再能被抗免疫球蛋白抗体识别的免疫球蛋白的改变形式。罗素体的不均匀染色模式进一步表明罗素体在性质上可能是异质的。
Russell bodies have been previously regarded as aggregates of immunoglobulin. Light and electron microscopic immunoperoxidase studies show no detectable immunoglobulin determinants in the Russell body cores. Denaturation of antigens during tissue preparation appears to be an unlikely explanation, since immunoglobulins in the cytoplasm of plasma cells are clearly demonstrated. The presence of immunoglobulins on the surface of small intracellular Russell bodies may represent the immunoglobulin determinants in the surrounding rough endoplasmic reticulum. It seems likely that Russell bodies contain non-immunoglobulin molecules, by-products of immunoglobulin synthesis, or some altered form of immunoglobulins that no longer can be recognized by the anti-immunoglobulin antibody. The non-uniform dye staining pattern of Russell bodies further suggests that Russell bodies may be heterogenous in nature.