Functions of AP1 (Fos/Jun) in bone development
Functions of AP1 (Fos/Jun) in bone development
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DOI：
10.1136/ard.61.suppl_2.ii40
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发表时间：
2002-11-01
影响因子：
27.4
通讯作者：
Wagner, EF
中科院分区：
文献类型：
--
作者：
Wagner, EF
转基因小鼠和细胞为二聚体转录因子复合物 AP1 的生物学功能，特别是其在骨骼发育中的作用提供了重要的见解。从基因敲除小鼠获得的数据显示，一些成分（例如 c-Fos）是骨细胞分化的关键调节因子，而其他成分（例如 c-Jun、Jun-B 和 Fra-1）对于胚胎和/或出生后发育至关重要。除了确定 AP1 蛋白在发育过程中的具体作用外，研究人员还开始更好地了解它们的细胞背景依赖性功能、下游靶基因以及它们如何调节骨细胞增殖、分化和凋亡。
Genetically modified mice and cells have provided important insights into the biological functions of the dimeric transcription factor complex AP1, in particular into its role in skeletal development. Data obtained from knockout mice revealed that some components, such as c-Fos are key regulators of bone cell differentiation, whereas others, like c-Jun, Jun-B and Fra-1 are essential in embryonic and/or postnatal development. Apart from identifying the specific roles of AP1 proteins in developmental processes, researchers are beginning to obtain a better molecular understanding of their cell-context dependent functions, their downstream target genes and how they regulate bone cell proliferation, differentiation, and apoptosis.