Antibody is required for protection against virulent but not attenuated Salmonella enterica serovar typhimurium
Antibody is required for protection against virulent but not attenuated Salmonella enterica serovar typhimurium
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DOI：
10.1128/iai.68.6.3344-3348.2000
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发表时间：
2000-06-01
影响因子：
3.1
通讯作者：
Jenkins, MK
中科院分区：
文献类型：
--
作者：
McSorley, SJ;Jenkins, MK
减毒沙门氏菌感染的解决是一个活跃的过程，需要CD4(+)T细胞。在这里，我们证明，清除减毒鼠伤寒沙门氏菌需要通过表面分子CD28的共刺激，而不是B细胞产生的抗体。相比之下，特定抗体对于疫苗诱导的对毒力细菌的保护至关重要。因此，CD28(+)CD4(+)T细胞足以清除幼稚宿主中的无毒沙门氏菌，而免疫宿主中需要CD4(+)T细胞和特异性抗体来保护其免受强毒沙门氏菌的侵袭。
Resolution of infection with attenuated Salmonella is an active process that requires CD4(+) T cells. Here, we demonstrate that costimulation via the surface molecule CD28, but not antibody production by B cells, is required for clearance of attenuated aroA Salmonella enterica serovar typhimurium. In contrast, specific antibody is critical for vaccine-induced protection against virulent bacteria. Therefore, CD28(+) CD4(+) T tells are sufficient for clearance of avirulent Salmonella in naive hosts, whereas CD4(+) T cells and specific antibodies are required for protection from virulent Salmonella in immune hosts.