Application value of nomogram and prognostic factors of gastric cancer patients who underwent D2 radical lymphadenectomy
Application value of nomogram and prognostic factors of gastric cancer patients who underwent D2 radical lymphadenectomy
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DOI：
10.1186/s12876-019-1098-6
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发表时间：
2019-11-15
影响因子：
2.4
通讯作者：
Chen, Zhi-Bai
中科院分区：
文献类型：
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作者：
Mu, Guang-Chuan;Huang, Yuan;Chen, Zhi-Bai
本研究的目的是探讨影响胃癌患者预后的因素，并建立预测胃癌患者长期生存的nomogram。方法收集2009年1月至2017年3月同一手术组行根治性D2淋巴结切除术的421例胃癌患者的临床病理资料。长期生存分析采用Cox回归分析。根据多因素分析结果，制定预测5年生存率概率的预后nomogram。结果本组患者3年生存率为58.7%，5年生存率为45.8%。单因素Cox回归分析结果显示，肿瘤分期、肿瘤位置、Borrmann型、淋巴结清扫数、淋巴结转移数、阳性淋巴结比例、淋巴细胞计数、血清白蛋白、CEA、CA153、CA199、BMI、肿瘤大小、神经侵犯、血管侵犯是胃癌的预后因素(均P
BackgroundThe aim of this study was to explore the prognostic factors and establish a nomogram to predict the long-term survival of gastric cancer patients.MethodsThe clinicopathological data of 421 gastric cancer patients, who were treated with radical D2 lymphadenectomy by the same surgical team between January 2009 and March 2017, were collected. The analysis of long-term survival was performed using Cox regression analysis. Based on the multivariate analysis results, a prognostic nomogram was formulated to predict the 5-year survival rate probability.ResultsIn the present study, the total overall 3-year and 5-year survival rates were 58.7 and 45.8%, respectively. The results of the univariate Cox regression analysis revealed that tumor staging, tumor location, Borrmann type, the number of lymph nodes dissected, the number of lymph node metastases, positive lymph nodes ratio, lymphocyte count, serum albumin, CEA, CA153, CA199, BMI, tumor size, nerve invasion, and vascular invasion were prognostic factors for gastric cancer (all, P