In vivo inhibition of veratridine-evoked release of striatal excitatory amino acids by the group II metabotropic glutamate receptor agonist LY354740 in rats
In vivo inhibition of veratridine-evoked release of striatal excitatory amino acids by the group II metabotropic glutamate receptor agonist LY354740 in rats
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DOI：
10.1016/s0304-3940(97)00442-4
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发表时间：
1997-07-04
影响因子：
2.5
通讯作者：
Schoepp, DD
中科院分区：
文献类型：
--
作者：
Battaglia, G;Monn, JA;Schoepp, DD
通过自由活动大鼠体内微透析研究LY354740（一种新型的、有效的、选择性的、系统活性的II组代谢性谷氨酸受体激动剂）改变谷氨酸神经元传递的突触前机制。LY354740 （10 mg/kg i.p）处理动物纹状体透析液中谷氨酸和天冬氨酸的基础水平与盐水处理的对照动物无显著差异。在生理盐水处理的对照组中，veratridine （100 μ M）诱导谷氨酸增加6倍，天冬氨酸增加9倍。然而，给药LY354740后，缬草碱诱发的谷氨酸和天冬氨酸释放完全被阻止。这些数据表明LY354740阻断了内源性兴奋性氨基酸的释放，并表明II组mGluRs在体内谷氨酸神经元传递的突触前调节中起作用。(C) 1997爱思唯尔科学爱尔兰有限公司
In vivo microdialysis in freely moving rats was used to investigate the presynaptic mechanisms by which LY354740, a novel, potent, selective, and systemically active agonist for group II metabotropic glutamate receptors (mGluRs), alters glutamate neuronal transmission. Basal levels of glutamate and aspartate in striatal dialysates of LY354740 (10 mg/kg i.p.)-treated animals were not significantly different from the saline-treated control animals. In the saline treated controls, veratridine (100 mu M) induced a 6-fold increase in glutamate and 9-fold increase in aspartate. However, following LY354740 administration the veratridine-evoked release of glutamate and aspartate was completely prevented. These data demonstrate that LY354740 blocks the evoked release of endogenous excitatory amino acids, and indicate a role for group II mGluRs in presynaptic modulation of glutamate neuronal transmission in vivo. (C) 1997 Elsevier Science Ireland Ltd.