Discriminant Analysis of Principle Component analyses of Physiological Data

Discriminant Analysis of Principle Component analyses of Physiological Data
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生理数据主成分分析的判别分析

DOI:
10.1101/2020.01.09.899898
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发表时间:
2020
期刊:
--
影响因子:
--
通讯作者:
Haidar O
Haidar O
中科院分区:
--
文献类型:
--
作者:
Haidar O

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在生理学和药理学分析中有许多情况需要收集多变量数据。通常,这些分析采用t检验和多重(Bonferroni)比较或ANOVA与事后检验。越来越多,即使有更强大的计算机许多变量,似乎特征减少将是一个有用的方法。最常用的方法是主成分分析,但在这份报告中,我们比较这一技术开发的遗传分析,判别分析的主成分(DAPC)分析。存在一个简单易用且维护良好的DAPC分析库Adegenet,使用该库,我们发现DAPC检测合成生理数据集之间的差异,其准确性显著高于传统PCA。
There are many situations in physiological and pharmacological analyses where multivariate data is collected. Frequently these are analysed with t-tests and multiple (Bonferroni) comparisons or ANOVA with post-hoc test. Increasingly, even with more powerful computers many variables and it seems that feature reduction would be a useful approach. The most commonly used method is principle component analyses, but in this report we compare this to a technique developed for genetic analyses, discriminant analysis of principle component (DAPC) analyses. A simple to use and well-maintained library exists for DAPC analyses, Adegenet, and using this we find that DAPC detects differences between synthetic physiological datasets with significantly greater accuracy than traditional PCA.
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发表时间: 2017
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影响因子: 5.8
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