Effects of loxoprofen sodium, a newly synthesized non‐steroidal anti‐inflammatory drug, and indomethacin on gastric mucosal haemodynamics in the human
Effects of loxoprofen sodium, a newly synthesized non‐steroidal anti‐inflammatory drug, and indomethacin on gastric mucosal haemodynamics in the human
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新合成非甾体抗炎药洛索洛芬钠与吲哚美辛对人胃粘膜血流动力学的影响
DOI：
10.1111/j.1440-1746.1995.tb01053.x
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发表时间：
1995
影响因子：
4.1
通讯作者：
T. Kamada
中科院分区：
文献类型：
--
作者：
S. Kawano;Shingo Tsuji;N. Hayashi;Y. Takei;K. Nagano;H. Fusamoto;T. Kamada
摘要：非甾体抗炎药（NSAID）经常被用于缓解患者的疼痛；然而，已知它们在实验动物和人类中引起胃粘膜损伤。正如我们之前报道的那样，胃黏膜血流量减少在急性胃黏膜损伤的病因学中也起着重要作用。本研究采用反射分光光度法研究了新合成的非甾体抗炎药loxoprofen钠（2[p‐2氧环戊基甲基）苯基钠]丙酸二水合物对胃粘膜血流动力学的影响。在5名志愿者中使用了单方法和交叉方法。洛索洛芬钠60 mg（1片）或吲哚美辛25 mg（1片），用10 mL水稀释，25℃下，经插入内镜活检通道的聚乙烯管喷洒在胃粘膜上。给药后每隔5分钟取一次反射光谱，持续30分钟。粘膜血红蛋白含量（IHb）和血红蛋白氧饱和度（ISO2）的指标由作者先前报道的方法测定。吲哚美辛使IHb和ISO2值显著下降，表明缺血。然而，洛索洛芬钠在这两个参数上没有显著差异。吲哚美辛组出血糜烂明显，洛索洛芬钠组未见出血糜烂。在此基础上得出的结论是，loxoprofen钠一次性局部应用比吲哚美辛更安全。
Abstract Non‐steroidal anti‐inflammatory drugs (NSAID) are, and have been, frequently used for alleviation of pain in patients; however, they are known to cause gastric mucosal injury in experimental animals and in humans. A decrease in the gastric mucosal blood flow also plays an important role in the aetiology of acute gastric mucosal injury, as we previously reported. This study investigated the effect of a newly synthesized NSAID, loxoprofen sodium (sodium 2[p‐2 oxocyclopentylmethyl) phenyl]propionate dihydrate, on gastric mucosal haemodynamics using a reflectance spectrophotometry system. Both single and cross‐over methods were used in five volunteer subjects. Loxoprofen sodium 60 mg (one tablet) or indomethacin 25 mg (one tablet), was diluted in 10 mL water at 25°C and sprayed on the gastric mucosa via a polyethylene tube inserted into the biopsy channel of an endoscope. After drug administration, reflectance spectra were taken every 5 min for 30 min. The indices of mucosal haemoglobin content (IHb) and oxygen saturation of haemoglobin (ISO2) were determined by the method previously reported by the authors. Indomethacin administration produced a significant decrease in both IHb and ISO2 values, indication ischaemia. Loxoprofen sodium, however, showed no significant differences in either of the parameters. Haemorrhagic erosions were evident after indomethacin administration, but none were found after loxoprofen sodium administration. The conclusion reached on the basis of this evidence is that one‐time topical application of loxoprofen sodium is safer than indomethacin.