The pathology of asthma: brief review
The pathology of asthma: brief review
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DOI：
10.1016/s0162-3109(00)00238-1
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发表时间：
2000-07-25
期刊：
影响因子：
--
通讯作者：
Hegele, RG
中科院分区：
文献类型：
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作者：
Hegele, RG
哮喘患者存在慢性气道炎症已有世纪的历史，但这种炎症过程与可逆性气流阻塞和非特异性支气管高反应性的发病机制之间的关系仍不清楚。近年来，随着对哮喘患者下呼吸道的采样能力的提高，以及免疫学和分子生物学的革命性进展，对哮喘发病机制中涉及的炎症细胞和介质进行了广泛的评估。此外，越来越多的人认识到，以气道壁所有隔室增厚为特征的气道重塑可能对哮喘中气道狭窄的机制具有深远的影响，并有助于疾病的慢性化和进展。在这篇简短的综述中，我将描述哮喘的大体和微观病理学，气道重塑的过程及其功能后果，并推测未来的方向，以提高我们对哮喘的结构变化及其致病作用的理解。(C)2000 Elsevier Science B.V.保留所有权利。
The presence of chronic airway inflammation in asthmatic patients has been known for over a century, but the relationship of this inflammatory process to the pathogenesis of reversible airflow obstruction and non-specific bronchial hyperresponsiveness remains unclear. In recent years, the increasing ability to sample the lower respiratory tract of living asthmatic patients, coupled with revolutionary advances in immunology and molecular biology, has resulted in extensive evaluation of inflammatory cells and mediators implicated in the pathogenesis of asthma. In addition, there is increasing recognition that airway remodeling, characterized by thickening of all compartments of the airway wall, may have profound consequences on the mechanics of airway narrowing in asthma and contribute to the chronicity and progression of the disease. In this brief review, I will describe the gross and microscopic pathology of asthma, the process of airway remodeling and its functional consequences, and speculate on future directions to improve our understanding of the structural changes of asthma and their pathogenic role. (C) 2000 Elsevier Science B.V. All rights reserved.