MicroRNA-409-3p regulates cell proliferation and apoptosis by targeting PHF10 in gastric cancer
MicroRNA-409-3p regulates cell proliferation and apoptosis by targeting PHF10 in gastric cancer
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MicroRNA-409-3p 通过靶向胃癌中的 PHF10 来调节细胞增殖和凋亡。
DOI：
10.1016/j.canlet.2012.02.030
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发表时间：
2012-07-28
期刊：
影响因子：
9.7
通讯作者：
Liu, Bingya
中科院分区：
文献类型：
--
作者：
Li, Chenglong;Nie, Hui;Liu, Bingya
新的证据表明，microRNAs参与了肿瘤的发生和发展，起到了肿瘤抑制基因或癌基因的作用。在此，我们报道miR-409-3p在胃癌细胞系和组织中的表达显著下调。在SGC-7901胃癌细胞中过表达miR-409-3p在体内外均能显著抑制细胞增殖和诱导细胞凋亡。此外，我们还证明了转录调控因子PHF10是miR-409-3P的靶标。综上所述，这些发现提示miR-409-3p可能是一种新的胃癌抑制因子，其抗肿瘤活性可能与PHF10的直接靶向和抑制作用有关。(C)2012爱思唯尔爱尔兰有限公司。保留所有权利。
Emerging evidence has indicated microRNAs are involved in tumor development and progression, acting as tumor suppressors or oncogenes. Here we report that miR-409-3p was significantly downregulated in gastric cancer (GC) cell lines and tissues. Overexpression of miR-409-3p in SGC-7901 gastric cancer cells dramatically suppressed cell proliferation and induced cell apoptosis both in vitro and in vivo. Furthermore, we demonstrate that the transcriptional regulator PHF10 was a target of miR-409-3p. Taken together, these findings suggest that miR-409-3p may function as a novel tumor suppressor in GC and its anti-oncogenic activity may involve the direct targeting and inhibition of PHF10. (C) 2012 Elsevier Ireland Ltd. All rights reserved.