The role of exosomal non-coding RNAs in cancer metastasis.
The role of exosomal non-coding RNAs in cancer metastasis.
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DOI：
10.18632/oncotarget.23552
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发表时间：
2018-02-23
期刊：
影响因子：
--
通讯作者：
Xiong F
中科院分区：
文献类型：
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作者：
Wang JP;Tang YY;Fan CM;Guo C;Zhou YH;Li Z;Li XL;Li Y;Li GY;Xiong W;Zeng ZY;Xiong F
越来越多的研究证实，在真核生物中，许多细胞都能分泌囊泡或外体，其中含有重要的核酸、蛋白质和脂质，在细胞通讯和肿瘤转移中发挥着重要作用。本文综述了外体非编码RNA的综合功能。虽然已有研究表明，外切体介导瘤细胞信号转导，但肿瘤转移的作用机制尚不清楚。本文就外体非编码RNA在肿瘤微环境中介导肿瘤转移的作用进行综述，以期为肿瘤病理生理学研究提供新的思路。
An increasing number of studies has confirmed that many cells can secrete vesicles or exosomes in eukaryotes, which contain important nucleic acids, proteins and lipids and play important roles in cell communication and tumor metastasis. This paper summarizes the comprehensive function of exosomal non-coding RNAs. Although some studies have shown that exosomes mediate tumor signal transduction, the functional mechanism of the tumor metastasis remains to be elucidated. In this paper, we reviewed the role of exosomal non-coding RNAs in mediating cancer metastasis in the tumor microenvironment to provide new ideas for the study of tumor pathophysiology.