Ciliary neurotrophic factor reduces the proliferation and promotes the differentiation of TH- MYCN transformed sympathoadrenal progenitors.
Ciliary neurotrophic factor reduces the proliferation and promotes the differentiation of TH- MYCN transformed sympathoadrenal progenitors.
复制标题
睫状神经营养因子减少TH-MYCN转化的交感肾上腺祖细胞的增殖并促进其分化。
DOI：
10.1159/000365281
复制
发表时间：
2014
影响因子：
2.9
通讯作者：
Nishi,Rae
中科院分区：
文献类型：
--
作者：
DeWitt,John;Pappas,Anthony;Nishi,Rae
神经母细胞瘤是一种由交感肾上腺祖细胞转化引起的儿童癌症。通过跟踪纯合TH-MYCN小鼠（一种已建立的神经母细胞瘤小鼠模型）中肿瘤的形成，我们能够在形成大的血管化肿瘤之前捕获转化细胞，以确定细胞对神经营养因子的反应性。我们发现睫状神经营养因子（CNTF）受体在这些小鼠的肿瘤细胞中大量表达。此外，CNTF，而不是神经生长因子，脑源性神经生长因子，神经营养因子3，或胶质细胞系源性神经营养因子促进神经元分化和退出细胞周期。因此，通过MYCN过表达的交感肾上腺祖细胞的转化差异地影响对神经营养分子的反应。
Neuroblastoma is a childhood cancer caused by the transformation of sympathoadrenal progenitors. By following the formation of tumors in homozygous TH-MYCN mice, an established mouse model of neuroblastoma, we were able to capture transformed cells prior to the formation of large, vascularized tumors in order to determine the responsiveness of cells to neurotrophic factors. We discovered that the ciliary neurotrophic factor (CNTF) receptor is abundantly expressed in tumor cells from these mice. Furthermore, CNTF-but not nerve growth factor, brain-derived nerve growth factor, neurotrophin 3, or glial cell line-derived neurotrophic factor-promoted neuronal differentiation and withdrawal from the cell cycle. Thus, the transformation of sympathoadrenal progenitors by MYCN overexpression differentially affects responsiveness to neurotrophic molecules.