The mycobiota of the human body: a spark can start a prairie fire
The mycobiota of the human body: a spark can start a prairie fire
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DOI：
10.1080/19490976.2020.1731287
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发表时间：
2020-03
期刊：
影响因子：
12.2
通讯作者：
Di Zhang;Ying Wang;S. Shen;Yayi Hou;Yu-gen Chen;Tingting Wang
中科院分区：
文献类型：
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作者：
Di Zhang;Ying Wang;S. Shen;Yayi Hou;Yu-gen Chen;Tingting Wang
摘要真菌与人类健康密不可分，动摇了细菌在微生物中的独特地位。令人惊讶的是，这个看似微小的物种却能引发人体的巨大变化。菌群的失调和入侵被证实会导致身体不同部位的疾病。与此同时，我们的身体也会在真菌感染时产生相应的免疫变化。最近的几项研究已经将肠道菌群与人体免疫系统联系起来。本文主要介绍了与真菌相关的问题，首先介绍了真菌的种类，然后总结了由真菌在人体不同部位引起的典型疾病。此外，我们还从遗传学和免疫学的角度构建了人类抗真菌免疫系统的框架。最后，对真菌检测方法的研究进展进行了综述。
ABSTRACT Mycobiota are inseparable from human health, shaking up the unique position held by bacteria among microorganisms. What is surprising is that this seemingly small species can trigger huge changes in the human body. Dysbiosis and invasion of mycobiota are confirmed to cause disease in different parts of the body. Meanwhile, our body also produces corresponding immune changes upon mycobiota infection. Several recent studies have made a connection between intestinal mycobiota and the human immune system. In this review, we focus on questions related to mycobiota, starting with an introduction of select species, then we summarize the typical diseases caused by mycobiota in different parts of the human body. Moreover, we constructed a framework for the human anti-fungal immune system based on genetics and immunology. Finally, the progression of fungal detection methods is also reviewed.