Fractional anisotropy values detect pyramidal tract involvement in multiple system atrophy
Fractional anisotropy values detect pyramidal tract involvement in multiple system atrophy
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DOI：
10.1016/j.jns.2008.03.013
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发表时间：
2008-08-15
影响因子：
4.4
通讯作者：
Sobue, Gen
中科院分区：
文献类型：
--
作者：
Ito, Mizuki;Watanabe, Hirohisa;Sobue, Gen
目的：病理学研究显示多系统萎缩（MSA）有明显的锥体束受累，而临床锥体束体征相对罕见。我们研究了分数各向异性 (FA) 值，以评估 MSA 中锥体束受累的程度，并与肌萎缩侧索硬化症 (ALS) 和对照进行比较。此外，我们还比较了有或没有临床锥体体征的 MSA 患者和对照之间，以及有或没有阳性常规 MRI 结果和对照的 MSA 患者之间的 FA 值。方法：我们使用 3.0T 磁共振系统，对 65 名受试者（20 名疑似 MSA 患者、28 名年龄匹配的 ALS 患者和 17 名年龄匹配的健康对照）进行可视化纤维束成像，评估内囊、放射冠和整个锥体束的 FA 值。 MSA 患者内囊、放射冠和整个锥体束的 FA 值显着低于对照组，与 ALS 患者的水平相似。此外，低FA值在MSA患者中也很突出，即使是那些病程较短、FLAIR图像中缺乏中央前回高信号且无锥体征的患者也是如此。结论：即使在早期MSA患者和无临床锥体征或MRI异常表现的患者中，FA值也可以识别锥体束变性。 MSA 中发生的锥体束变性比目前认为的更为广泛。 (C) 2008 Elsevier B.V. 保留所有权利。
Objective: Pathological studies have shown remarkable pyramidal tract involvement in multiple system atrophy (MSA), while clinical Pyramidal signs are relatively rare. We investigated the fractional anisotropy (FA) values to assess the degree of pyramidal tract involvement in MSA, in comparison with amyotrophic lateral sclerosis (ALS) and controls. Furthermore, we compared FA values between MSA patients with or without clinical pyramidal signs and controls, and between MSA patients with or without positive conventional MRI findings and controls.Methods: We evaluated FA values in the internal capsule, corona radiate and whole pyramidal tract using visualized tractography of 65 subjects (20 probable MSA patients, 28 age-matched ALS patients, and 17 age-matched healthy controls) using a 3.0T magnetic resonance system.Results: The FA values in the internal capsule, corona radiate, and whole pyramidal tract were significantly lower in MSA patients than in controls and were at a level similar to those of ALS patients. In addition, low FA values were prominent in MSA patients, even in those with short duration of illness, lacking precentral gyrus hyperintensity in FLAIR images, and without pyramidal signs.Conclusion: FA values could identify pyramidal tract degeneration even in patients with early phase MSA and those without clinical pyramidal signs or abnormal MRI findings. More extensive degeneration of the pyramidal tract occurs in MSA than so far believed. (C) 2008 Elsevier B.V. All rights reserved.