Studies on L-ascorbic acid metabolism in rats under chronic toxicity due to organophosphorus insecticides: effects of supplementation of L-ascorbic acid in high doses.
Studies on L-ascorbic acid metabolism in rats under chronic toxicity due to organophosphorus insecticides: effects of supplementation of L-ascorbic acid in high doses.
复制标题
有机磷杀虫剂慢性毒性大鼠L-抗坏血酸代谢研究：大剂量补充L-抗坏血酸的影响。
DOI：
10.1093/jn/108.6.973
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发表时间：
1978
期刊：
影响因子：
--
通讯作者：
G. Chatterjee
中科院分区：
文献类型：
--
作者：
D. Chakraborty;A. Bhattacharyya;K. Majumdar;K. Chatterjee;S. Chatterjee;A. Sen;G. Chatterjee
本文研究了两种有机磷杀虫剂--马拉硫磷和敌敌畏的毒性均使大鼠的生长速度减慢。以脑乙酰胆碱酯酶抑制率作为有机磷农药毒性的指标。在毒性条件下，血液血红蛋白浓度和器官重量不受影响。对硫磷和马拉硫磷给药刺激了L-古洛糖酸内酯氧化酶的活性，同时沿着维生素C的组织储存和尿排泄增加。在实验条件下，抗坏血酸代谢的其他酶，脱氢抗坏血酸酶，糖醛酸内酯酶，L-古洛酸脱氢酶和脱羧酶的活性被改变。在对硫磷和马拉硫磷毒性下，仅观察到肝脏和肾脏组织的轻微组织学变化。在毒性条件下过量摄入维生素C被认为是非常有效的，在抵消生长迟缓，也产生的变化，由马拉硫磷和马拉硫磷在酶和组织学水平。
The effects of chronic administration of two organophosphorus insecticides, parathion and malathion on the growth rate, ascorbic acid metabolism and some other nutritional and physiological parameters in rats were studied. Both parathion and malathion toxicity retarded the growth rate of rats. Inhibition of brain acetylcholinesterase was taken as an index of organophosphorus insecticide toxicity. Haemoglobin concentration of blood and organ weights were not affected under the toxic conditions. Parathion and malathion administration stimulated the activity of L-gulonolactone oxidase along with a simultaneous increase in the tissue storage and urinary excretion of vitamin C. The activities of other enzymes of ascorbic acid metabolism, dehydroascorbatase, uronolactonase, and L-gulonate dehydrogenase and decarboxylase were altered under the experimental conditions. Only minor histological changes of the liver and kidney tissues were noted under parathion and malathion toxicities. Excess intake of vitamin C under the toxic conditions was found to be very effective in counteracting the growth retardation and also the alterations produced by parathion and malathion both at the enzymatic and histological levels.