Meibomian Glands and Ocular Surface Inflammation
Meibomian Glands and Ocular Surface Inflammation
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DOI：
10.1016/j.jtos.2014.12.002
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发表时间：
2015-04-01
期刊：
影响因子：
6.4
通讯作者：
Kinoshita, Shigeru
中科院分区：
文献类型：
--
作者：
Suzuki, Tomo;Teramukai, Satoshi;Kinoshita, Shigeru
本综述的目的是系统分析与睑板腺疾病在眼表炎症中的作用相关的出版物，特别提到睑板炎是睑板腺功能障碍（MGD）的一种炎症形式。睑板腺炎症通常与眼表炎症一起出现在眼睑角结膜炎、眼红斑痤疮和泡性角膜炎等疾病中，但其作用往往被忽视，尤其是在年轻受试者中。这可能导致误诊、误治，有时甚至严重的视力障碍。我们确定了一个相关的疾病实体，主要见于年轻患者，眼表炎症与睑板炎，我们称之为睑板炎相关的角结膜炎。其具体的临床特征与上述疾病中观察到的相似，并且基于我们的统计评估，发现MGD的炎性形式与这四种疾病中观察到的眼表炎症密切相关。睑板炎是MGD的一种炎症形式，其诊断和治疗对于成功治疗诱导的眼表炎症至关重要。我们建议眼表和附属睑板腺应视为一个单位，即，在临床环境中遇到的“睑板腺和眼表”（MOS）。
The purpose of this review was to systematically analyze publications related to the role of meibomian gland disease in ocular surface inflammation, with special reference to meibomitis as an inflammatory form of meibomian gland dysfunction (MGD). Meibomian gland inflammation is often present with the ocular surface inflammation in conditions such as blepharokeratoconjunctivitis, ocular rosacea, and phlyctenular keratitis, but its contribution is often overlooked, especially in younger subjects. This can result in misdiagnosis, mistreatment, and, sometimes, severe visual impairment. We identified a related disease entity, seen predominantly in young patients, of ocular surface inflammation associated with meibomitis, which we termed meibomitis-related keratoconjunctivitis. Its specific clinical features are similar to those observed in the above-mentioned diseases, and the inflammatory form of MGD was found to be closely involved in the ocular surface inflammation seen in those four diseases, based on our statistical evaluation. The diagnosis and management of meibomitis, an inflammatory form of MGD, is vital for the successful treatment of the induced ocular surface inflammation. We propose that the ocular surface and the adnexal meibomian glands should be considered as one unit, i.e., the "meibomian gland and ocular surface" (MOS), when encountered in the clinical setting.