Oral status, oral infections and some lifestyle factors as risk factors for oral and oropharyngeal squamous cell carcinoma:: A population-based case-control study in southern Sweden
Oral status, oral infections and some lifestyle factors as risk factors for oral and oropharyngeal squamous cell carcinoma:: A population-based case-control study in southern Sweden
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DOI：
10.1080/00016480510012273
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发表时间：
2005-12-01
影响因子：
1.4
通讯作者：
Andersson, G
中科院分区：
文献类型：
--
作者：
Rosenquist, K;Wennerberg, J;Andersson, G
结论我们的研究结果表明，平均和不良的口腔卫生和不适当的牙齿状况是口腔和口咽鳞状细胞癌（OOSCC）的独立危险因素，无论烟草和酒精消费。Objective.通过一项基于人群的病例对照研究，评估口腔癌、口腔卫生、牙齿状况、口腔粘膜病变和某些生活方式因素之间的可能关系。材料和方法。在2000年9月至2004年1月期间，132/ 165（80%）的所有OOSCC事件病例和320/ 396（81%）的预期合格匹配对照参与了研究。病例组和对照组进行相同的口腔检查。使用专门为研究设计的标准化方案。结果在调整烟草和酒精消费后，平均口腔卫生（OR 2.0; 95%CI 1.1 - 3.6）和口腔卫生不良（OR 5.3; 95%CI 2.5 - 11.3）是OOSCC的重要危险因素。缺失牙齿超过20颗（OR 3.4; 95%CI 1.4 - 8.5）、缺损牙齿超过5颗（OR 3.1; 95%CI 1.2 - 8.2）和全口义齿不合适或有缺陷（OR 3.8; 95%CI 1.3 - 11.4）是显著的风险因素。定期牙科检查与OOSCC风险降低相关（OR 0.4; 95%CI 0.2 - 0.6）.
Conclusion. Our results show that average and poor oral hygiene and inadequate dental status are independent risk factors for oral and oropharyngeal squamous cell carcinoma ( OOSCC), irrespective of tobacco and alcohol consumption. Objective. To evaluate a possible relationship between oral cancer, oral hygiene, dental status, oral mucosal lesions and some lifestyle factors in a population- based case- control study. Material and methods. Between September 2000 and January 2004, 132/ 165 ( 80%) of all incident cases of OOSCC and 320/ 396 ( 81%) of the intended eligible matched controls participated in the study. Cases and controls were subjected to an identical oral examination. A standardized protocol specially designed for the study was used. Results. After adjusting for tobacco and alcohol consumption, average oral hygiene ( OR 2.0; 95% CI 1.1 - 3.6) and poor oral hygiene ( OR 5.3; 95% CI 2.5 - 11.3) emerged as significant risk factors for OOSCC. More than 20 lost teeth ( OR 3.4; 95% CI 1.4 - 8.5), > 5 defective teeth ( OR 3.1; 95% CI 1.2 - 8.2) and poorly fitting or defective complete dentures ( OR 3.8; 95% CI 1.3 - 11.4) were significant risk factors. Regular dental check- ups were associated with a decreased risk of OOSCC ( OR 0.4; 95% CI 0.2 - 0.6).