Low plasma adiponectin level, white blood cell count and Helicobacter pylori titre independently predict abnormal pancreatic β-cell function
Low plasma adiponectin level, white blood cell count and Helicobacter pylori titre independently predict abnormal pancreatic β-cell function
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DOI：
10.1016/j.diabres.2009.08.010
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发表时间：
2009-11-01
影响因子：
5.1
通讯作者：
Chan, Juliana C.
中科院分区：
文献类型：
--
作者：
So, Wing-Yee;Tong, Peter C.;Chan, Juliana C.
脂联素是一种具有胰岛素增敏作用的脂肪细胞因子，而慢性炎症会损害胰腺β细胞，导致胰岛素反应降低。我们的目的是证明脂联素水平和炎症标志物（白细胞计数 [WCC]、幽门螺杆菌 [HP] 滴度、高敏 C 反应蛋白 [hs-CRP]）可能相互作用从而影响糖尿病风险的假设。我们研究了从香港社区招募的 288 名中国男性（年龄中位数：41.0 岁，IQR：35.3-46.0 岁）。平均脂联素水平为 5.39 +/- 2.81 mu g/ml，40.9% (n = 107) 脂联素水平较低（
Adiponectin is an adipocytokine with insulin sensitizing effect while chronic inflammation damages pancreatic beta-cells leading to reduced insulin response. We aimed to prove the hypothesis that adiponectin levels and inflammatory markers (white blood cell counts [WCC], Helicobacter pylori [HP] titers, high sensitivity C-reactive protein [hs-CRP]) may interact to affect risk of diabetes. We studied 288 Chinese men (age-median: 41.0 years, IQR: 35.3-46.0 years) being recruited from the community in Hong Kong. The mean adiponectin level was 5.39 +/- 2.81 mu g/ml and 40.9% (n = 107) had low adiponectin level (