Association of BMI, Smoking, and Alcohol with Multiple Myeloma Mortality in Asians: A Pooled Analysis of More than 800,000 Participants in the Asia Cohort Consortium.
Association of BMI, Smoking, and Alcohol with Multiple Myeloma Mortality in Asians: A Pooled Analysis of More than 800,000 Participants in the Asia Cohort Consortium.
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DOI：
10.1158/1055-9965.epi-19-0389
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发表时间：
2019-11
期刊：
影响因子：
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通讯作者：
Matsuo K
中科院分区：
文献类型：
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作者：
Ugai T;Ito H;Oze I;Saito E;Rahman MS;Boffetta P;Gupta PC;Sawada N;Tamakoshi A;Shu XO;Koh WP;Gao YT;Sadakane A;Tsuji I;Park SK;Nagata C;You SL;Pednekar MS;Tsugane S;Cai H;Yuan JM;Xiang YB;Ozasa K;Tomata Y;Kanemura S;Sugawara Y;Wada K;Chen CJ;Yoo KY;Chia KS;Ahsan H;Zheng W;Inoue M;Kang D;Potter J;Matsuo K
到目前为止，很少有流行病学研究来阐明生活方式相关的亚洲多发性骨髓瘤的危险因素。我们通过对亚洲队列联合会超过800,000名参与者的综合分析，调查了体重指数(BMI)、吸烟和饮酒与多发性骨髓瘤死亡风险的关系。这项分析包括805,309名参与者，他们在整个亚洲队列中贡献了10,221,623人年的累积随访。基线时体重指数、吸烟和饮酒与多发性骨髓瘤死亡风险之间的关联的小时比和95%可信区间(95%可信区间)通过具有共同脆弱性的Cox比例风险模型进行评估。我们观察到体重指数类别与多发性骨髓瘤死亡率之间存在显著的剂量依赖关系(≥30 kg/m2：HR=1.61，95%CI：0.99-2.64，P趋势=0.014)，体重指数：HR=0.80，95%CI：0.52-1.24；在性别方面，这种关联在女性中比在男性中更明显(P=0.150)。我们没有观察到吸烟或饮酒与多发性骨髓瘤死亡风险之间的显著关联。这项研究表明，在亚洲人群中，过多的身体质量与多发性骨髓瘤死亡的风险增加有关。相比之下，我们的结果不支持吸烟或饮酒与亚洲人群多发性骨髓瘤死亡风险之间的关联。这项研究为亚洲人群中体重指数、吸烟和饮酒与多发性骨髓瘤死亡风险之间的关系提供了重要证据。
To date, few epidemiologic studies have been conducted to elucidate lifestyle-related risk factors for multiple myeloma in Asia. We investigated the association of body mass index (BMI), smoking, and alcohol intake with the risk of multiple myeloma mortality through a pooled analysis of more than 800,000 participants in the Asia Cohort Consortium. The analysis included 805,309 participants contributing 10,221,623 person-years of accumulated follow-up across Asia Cohort Consortium cohorts. HRs and 95% confidence intervals (95% CI) for the association between BMI, smoking, and alcohol at baseline and the risk of multiple myeloma mortality were assessed using a Cox proportional hazards model with shared frailty. We observed a statistically significant dose-dependent association between BMI categories and the risk of multiple myeloma mortality (<18.5 kg/m2: HR = 0.80,95% CI: 0.52–1.24; 18.5–24.9 kg/m2: reference; 25.0–29.9 kg/m2: HR = 1.17, 95% CI: 0.94–1.47; ≥30 kg/m2: HR = 1.61, 95% CI: 0.99–2.64, Ptrend = 0.014). By sex, this association was more apparent in women than in men (P for heterogeneity between sexes = 0.150). We observed no significant associations between smoking or alcohol consumption and risk of multiple myeloma mortality. This study showed that excess body mass is associated with an increased risk of multiple myeloma mortality among Asian populations. In contrast, our results do not support an association between smoking or alcohol consumption and the risk of multiple myeloma mortality in Asian populations. This study provides important evidence on the association of BMI, smoking, and alcohol with the risk of multiple myeloma mortality in Asian populations.