The Therapeutic Effects of Curcumin in Early Septic Acute Kidney Injury: An Experimental Study.
The Therapeutic Effects of Curcumin in Early Septic Acute Kidney Injury: An Experimental Study.
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DOI：
10.2147/dddt.s332623
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Li Q
中科院分区：
文献类型：
--
作者：
Wang S;Zhao P;Zhang Y;Zhu L;Zhu J;Luo Y;Li Q
脓毒症是医院和重症监护室（ICU）中与急性肾损伤（阿基）相关的主要疾病，脓毒症诱导的阿基（S-AKI）与不良临床结局密切相关。姜黄素具有改善缺血-再灌注肾损伤的能力，但其是否具有减少S-AKI的能力仍是未知的。本研究的目的是研究姜黄素对S-AKI的保护作用，并评估其对肾功能，炎症反应和微循环灌注的治疗潜力。雄性Sprague-Dawley（SD）大鼠进行盲肠结扎和穿刺（CLP）以诱导S-AKI，并且在手术后立即接受媒介物（CLP组）或姜黄素（CLP+Cur组）。分别于术后12、24 h检测血清学指标、炎症因子、心输出量（CO）、肾血流量和微循环血流量。CLP+Cur组血清肌酐（Scr）、胱抑素C（CysC）、IL-6和TNF-α水平均显著低于CLP组（P < 0.05）。通过测量超声造影（CEUS）定量参数[峰值强度（PI）;一半下降时间（DT/2）;曲线下面积（AUC）; P < 0.05]，姜黄素治疗24小时后改善了肾脏微循环。在组织病理学分析中，姜黄素治疗减少了CLP引起的损伤。姜黄素可通过改善肾微循环灌注、减轻炎症反应减轻大鼠S-AKI。姜黄素可能是一种潜在的预防或减少S-AKI的新型治疗药物。
Sepsis is the leading condition associated with acute kidney injury (AKI) in the hospital and intensive care unit (ICU), sepsis-induced AKI (S-AKI) is strongly associated with poor clinical outcomes. Curcumin possesses an ability to ameliorate renal injury from ischemia-reperfusion, but it is still unknown whether they have the ability to reduce S-AKI. The aim of this study was to investigate the protective effects of curcumin on S-AKI and to assess its therapeutic potential on renal function, inflammatory response, and microcirculatory perfusion. Male Sprague-Dawley (SD) rats underwent cecal ligation and puncture (CLP) to induce S-AKI and immediately received vehicle (CLP group) or curcumin (CLP+Cur group) after surgery. At 12 and 24h after surgery, serum indexes, inflammatory factors, cardiac output (CO), renal blood flow and microcirculatory flow were measured. Serum levels of creatinine (Scr), cystatin C (CysC), IL-6 and TNF-α were significantly lower in the CLP+Cur group than those in the CLP group (P < 0.05). Treatment with curcumin improved renal microcirculation at 24h by measurement of contrast enhanced ultrasound (CEUS) quantitative parameters [peak intensity (PI); half of descending time (DT/2); area under curve (AUC); P < 0.05]. In histopathological analysis, treatment with curcumin reduced damage caused by CLP. Curcumin can alleviate S-AKI in rats by improving renal microcirculatory perfusion and reducing inflammatory response. Curcumin may be a potential novel therapeutic agent for the prevention or reduction of S-AKI.