S100A8/A9, a potent biomarker and clinical candidate for the treatment of uveitis
S100A8/A9, a potent biomarker and clinical candidate for the treatment of uveitis
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DOI：
10.14800/ics.1512
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发表时间：
2017-03
影响因子：
--
通讯作者：
Zai-Long Chi;Xiaodan Dai
中科院分区：
文献类型：
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作者：
Zai-Long Chi;Xiaodan Dai
葡萄膜炎是葡萄膜炎症的病理状态，通常会导致严重的视力障碍和失明。葡萄膜炎的可能原因包括感染、损伤、自身免疫性疾病或炎症性疾病。然而，葡萄膜炎的发病机制尚不完全清楚。糖皮质激素被广泛用于治疗葡萄膜炎，但长期使用类固醇有潜在并发症的风险。早期诊断和适当治疗对预防葡萄膜炎并发症至关重要。到目前为止，研究人员还没有找到一种有效的生物标志物来辅助诊断葡萄膜炎，也没有一种合适的方法来监测葡萄膜炎的炎症活性。S100A8/A9，又称钙保护蛋白，属于ca2 +结合蛋白S100家族；主要表达于髓系白细胞；并在多种病理过程中发挥突出作用，如炎症、感染和自身免疫性疾病。最近，粒细胞和单核细胞释放的胞外S100A8/A9作为炎症反应调节的关键警报因子受到了广泛关注。本文将对S100A8/A9在葡萄膜炎中的生物学功能的最新研究进展进行综述，并对S100A8/A9在葡萄膜炎诊断、炎症监测和治疗中的应用进行展望。
Uveitis, the pathological condition of inflammation of the uvea, commonly causes severe visual impairment and blindness. Possible causes of uveitis include infection, injury, or an autoimmune or inflammatory disease. However, the pathogenesis of uveitis is not fully understood. Glucocorticoids are widely used for the treatment of uveitis, but long-term steroid use carries a risk of potential complications. Early diagnosis and proper treatment are important to prevent the complications of uveitis. Thus far, researchers have not identified an effective biological marker for auxiliary diagnosis or an appropriate method for monitoring the inflammatory activity of uveitis. S100A8/A9, also known as calprotectin, belongs to the Ca 2+ -binding S100 protein family; is mainly expressed in myeloid leukocytes; and plays a prominent role in a variety of pathological process, such as inflammation, infection and autoimmune diseases. Extracellular S100A8/A9 released from granulocytes and monocytes has recently gained a great deal of attention as a critical alarmin for the modulation of the inflammatory response. This review will summarize recent insights into the biological function of S100A8/A9 in uveitis and provide an outlook on diagnostic, inflammation monitoring and therapeutic applications targeting S100A8/A9 for the treatment of uveitis.