The prognostic values of insulin-like growth factor binding protein in breast cancer
The prognostic values of insulin-like growth factor binding protein in breast cancer
复制标题
胰岛素样生长因子结合蛋白在乳腺癌中的预后价值
DOI：
10.1097/md.0000000000015561
复制
发表时间：
2019-05-01
期刊：
影响因子：
1.6
通讯作者：
Zeng, Zhen-Guo
中科院分区：
文献类型：
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作者：
Wang, Jiao;Luo, Xin-Xin;Zeng, Zhen-Guo
胰岛素样生长因子结合蛋白（IGFBPs）是一类与胰岛素样生长因子结合的蛋白质家族，通常由6个高亲和力的IGFBPs组成，分别为IGFBP 1 ~ IGFBP 6。IGFBP家族成员已被证明参与肿瘤的发生和进展，并可能是各种恶性肿瘤的有用的预后生物标志物。然而，个别IGFBPs的预后作用，特别是在乳腺癌患者的mRNA水平仍然难以捉摸。我们通过Kaplan-Meier曲线在线数据库和OncoLnc数据库评估IGFBPs家族（IGFBP 1 -6）在乳腺癌中的预后作用。我们的研究结果表明，IGFBP 1 mRNA的高表达与所有乳腺癌患者的良好无复发生存期（RFS）相关。在所有乳腺癌患者中，IGFBP 2 mRNA的高表达与良好的总生存期（OS）和RFS相关。IGFBP 3 mRNA的高表达与所有乳腺癌患者RFS的恶化显著相关。在所有乳腺癌患者中，IGFBP 4 mRNA的高表达与良好的OS、RFS、无远处转移生存率和进展后生存率相关。我们的研究结果表明，IGFBPs mRNA的表达可能对乳腺癌患者的预后有价值，并有助于开发更准确地预测预后的工具。
Abstract Insulin-like growth factor binding proteins (IGFBPs) are a family of proteins binding to insulin-like growth factors, generally consisting 6 high-affinity IGFBPs, namely IGFBP1 through IGFBP6. IGFBP family members have been indicated to be involved in the development and progression of tumors and may be useful prognostic biomarkers in various malignancies. However, the prognostic role of individual IGFBPs, especially at the mRNA level in breast cancer patients remains elusive. We accessed the prognostic roles of IGFBPs family (IGFBP1-6) in breast cancer through the “Kaplan–Meier plotter” online database and OncoLnc database. Our results showed that the high expression of IGFBP1 mRNA was associated with favorable relapsed free survival (RFS) in all breast cancer patients. The high expression of IGFBP2 mRNA was associated with favorable overall survival (OS) and RFS in all breast cancer patients. The high expression of IGFBP3 mRNA was significantly correlated to worsen RFS in all breast cancer patients. The high expression of IGFBP4 mRNA was associated with favorable OS, RFS, distant metastasis-free survival, and post-progression survival in all breast cancer patients. Our results indicated that expression of IGFBPs mRNA may have prognostic values in breast cancer patients, and have a benefit for developing tools to predict the prognosis more accurately.