Perivascular T cells express the pro-inflammatory chemokine RANTES mRNA in multiple sclerosis lesions
Perivascular T cells express the pro-inflammatory chemokine RANTES mRNA in multiple sclerosis lesions
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DOI：
10.1046/j.1365-3083.1997.d01-100.x
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发表时间：
1997-08-01
影响因子：
3.7
通讯作者：
Bernard, CCA
中科院分区：
文献类型：
--
作者：
Hvas, J;McLean, C;Bernard, CCA
多发性硬化（MS）是中枢神经系统（CNS）的炎性脱髓鞘疾病，其特征在于单核细胞的积聚。MS的发病机制是复杂的，并且可能涉及可溶性免疫介质，特别是细胞因子和活化的记忆T细胞，其被认为迁移到CNS中。在MS中的病变形成期间，细胞因子调节细胞功能，例如细胞募集和迁移。由于趋化因子RANTES在激活和招募白细胞（特别是记忆T细胞）进入炎症部位方面发挥作用，因此作者评估了病变部位的RANTES mRNA水平。分析了大脑样本中的表达水平，并与神经系统、感染性和其他对照进行了比较。RANTES由活化的血管周围记忆T细胞表达，主要位于活动斑块的边缘。虽然RANTES mRNA在所有分析的17个MS脑中检测到，但仅在14个对照患者中的6个中发现，并且通常处于较低的表达水平。鉴于RANTES的调节和趋化特性，这些结果意味着MS病变中的RANTES可能在记忆T细胞的激活和/或选择性蓄积中发挥重要作用，从而在与MS相关的致病事件中发挥重要作用。
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS), characterized by accumulation of mononuclear cells. The pathogenesis of MS is complex and probably involves soluble immune mediators, particularly cytokines, and activated memory T cells, that are thought to migrate into the CNS, During lesion formation in MS, cytokines regulate cell functions, such as cell recruitment and migration. Because the chemokine RANTES play a role in both activating and recruiting leucocytes, particularly memory T cells into inflammatory sites, the authors have assessed RANTES mRNA levels at the site of lesions. Expression levels were analysed in brain samples and compared with neurological, infectious and other controls. RANTES was expressed by activated perivascular memory T cells, predominantly located at the edge of active plaques. While RANTES mRNA was detected in all 17 MS brains analysed, it was only found in six of the 14 control patients and generally at a lower expression level. In view of the regulatory and chemotactic properties of RANTES, these results imply that RANTES in MS lesions may play an important role in the activation and/or selective accumulation of memory T cells and, thereby, in the pathogenic events associated with MS.