Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene
Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene
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DOI：
10.1038/386796a0
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发表时间：
1997-04-24
期刊：
影响因子：
64.8
通讯作者：
Weinberg, RA
中科院分区：
文献类型：
--
作者：
Fazeli, A;Dickinson, SL;Weinberg, RA
DCC基因是人类第一个发现的肿瘤抑制基因，位于人类染色体18 q上。最近，在啮齿动物的体外研究提供了证据，DCC可能作为轴突化学引诱剂netrin-1的受体。鼠Dcc基因的失活导致轴突投射缺陷，这与netrin-1缺陷小鼠中观察到的缺陷相似，但不影响小鼠肠中的生长、分化、形态发生或肿瘤发生。这些观察结果未能支持DCC的肿瘤抑制功能，但与DCC是netrin-1受体的组成部分的假设一致。
The DCC (Deleted in colorectal cancer) gene was first identified as a candidate for a tumour-suppressor gene on human chromosome 18q. More recently, in vitro studies In rodents have provided evidence that DCC might function as a receptor for the axonal chemoattractant netrin-1. Inactivation of the murine Dcc gene caused defects in axonal projections that are similar to those observed in netrin-1-deficient mice but did not affect growth, differentiation, morphogenesis or tumorigenesis in mouse intestine. These observations fail to support a tumour-suppressor function for Dcc, but are consistent with the hypothesis that DCC Is a component of a receptor for netrin-1.