Enzyme isoforms may increase phenotypic robustness.
Enzyme isoforms may increase phenotypic robustness.
复制标题
酶亚型可以提高表型的稳健性。
DOI：
10.1111/j.1558-5646.2008.00483.x
复制
发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Houle,David
中科院分区：
文献类型：
--
作者：
Tomaiuolo,Maurizio;Bertram,Richard;Houle,David
酶同工型存在于许多细胞反应中，并且在它们催化的反应类型、它们的底物亲和力或它们的反应速率方面可以不同。酶同工型的进化意义只是部分了解。我们使用数学建模来研究这样的假设，即同种型可能受到选择的青睐，因为它们可以增加系统的表型鲁棒性。我们修改了果蝇昼夜节律钟基因表达模型，将周期基因磷酸化途径中同工型的存在纳入其中。我们考虑的情况下，不同的异构体催化相同的反应，但有不同的亲和力的基板。如果存在异构体相对于彼此的表达的动态控制，则稳定性增加。因此，我们表明，控制异构体比例可以是一个强大的机制，减少系统参数值的变化的影响，增加系统的鲁棒性。
Enzyme isoforms are found in many cellular reactions, and can differ in the kind of reaction they catalyze, in their substrate affinity, or in their reaction rates. The evolutionary significance of enzyme isoforms is only partially understood. We used mathematical modeling to investigate the hypothesis that isoforms may be favored by selection because they can increase the phenotypic robustness of the system. We modify a model for circadian clock gene expression inDrosophilato incorporate the presence of isoforms in the phosphorylation pathway of theperiodgene. We consider the case in which different isoforms catalyze the same reaction but have different affinities for the substrate. Stability is increased if there is dynamic control of the expression of isoforms relative to each other. Thus, we show that controlling isoform proportion can be a powerful mechanism for reducing the effects of variations in the values of system parameters, increasing system robustness.