Self-selection of the analgesic drug carprofen by lame broiler chickens
Self-selection of the analgesic drug carprofen by lame broiler chickens
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DOI：
10.1136/vr.146.11.307
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发表时间：
2000-03-11
影响因子：
2.2
通讯作者：
Kestin, SC
中科院分区：
文献类型：
--
作者：
Danbury, TC;Weeks, CA;Kestin, SC
对从商业鸡群中选择的跛脚和健康肉鸡进行培训，以区分不同颜色的饲料，其中一种饲料含有卡洛芬。然后同时提供两种饲料，并允许鸡从两种饲料中选择自己的饲料，在评估最适当药物浓度的初始研究中，卡洛芬的血浆浓度与鸡的饲料摄入量呈线性相关。跛脚鸟的行走能力也以剂量依赖性方式显著改善，跛脚鸟倾向于比健全鸟消耗更多的镇痛剂。在第二项研究中，仅使用一种浓度的止痛剂，跛脚鸟选择的药物饲料明显多于健全鸟，最后，随着跛脚严重程度的增加，跛脚鸟消耗的药物饲料比例明显更高。
Lame and sound broilers, selected from commercial flocks, were trained to discriminate between different coloured feeds, one of which contained carprofen. The two feeds were then offered simultaneously and the birds were allowed to select their own diet from the two feeds, in an initial study to assess the most appropriate concentration of drug, the plasma concentrations of carprofen were linearly related to the birds' dietary intake. The walking ability of lame birds was also significantly improved in a dose-dependent manner and lame birds tended to consume more analgesic than sound birds. In a second study, in which only one concentration of analgesic was used, lame birds selected significantly more drugged feed than sound birds, end that as the severity of the lameness increased, lame birds consumed a significantly higher proportion of the drugged feed.