Urinary phthalates are associated with higher blood pressure in childhood.
Urinary phthalates are associated with higher blood pressure in childhood.
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DOI：
10.1016/j.jpeds.2013.03.072
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发表时间：
2013-09
期刊：
影响因子：
--
通讯作者：
Urbina EM
中科院分区：
文献类型：
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作者：
Trasande L;Sathyanarayana S;Spanier AJ;Trachtman H;Attina TM;Urbina EM
研究儿童尿邻苯二甲酸酯水平与血压（BP）、血清甘油三酯和脂蛋白水平的关系。我们对2003年至2008年期间参加国家健康和营养检查调查的6-19岁美国儿童的子样本进行了横断面分析。我们根据尿液代谢物的摩尔浓度，对3种邻苯二甲酸酯（低分子量、高分子量和邻苯二甲酸二（2-乙基己基）酯（DEHP））的暴露进行了定量。我们评估了描述性、双变量和多变量与血压和血脂水平的相关性。控制一系列社会人口统计学和行为因素，以及饮食和体重指数，DEHP（一种常见于加工食品中的邻苯二甲酸酯）的代谢物水平与较高的年龄、性别和身高标准化血压相关。DEHP代谢物每增加一个log单位（大约3倍），收缩压z评分增加0.041 SD单位（P = 0.047）。化妆品和个人护理产品中常见的低分子量邻苯二甲酸酯的代谢产物与BP无关。邻苯二甲酸酯代谢产物与甘油三酯水平、高密度脂蛋白水平或高血压前期无关。膳食邻苯二甲酸酯暴露与儿童和青少年收缩压升高相关。需要进一步的工作来确认这些关联，并评估干预的机会。
To examine associations of urinary phthalate levels with blood pressure (BP) and serum triglyceride and lipoprotein levels in children. We performed a cross-sectional analysis of a subsample of US children aged 6–19 years who participated in the National Health and Nutrition Examination Survey between 2003 and 2008. We quantified exposure to 3 families of phthalates—low molecular weight, high molecular weight and di-2-ethylhexylphthalate (DEHP)—based on molar concentration of urinary metabolites. We assessed descriptive, bivariate, and multivariate associations with BP and lipid levels. Controlling for an array of sociodemographic and behavioral factors, as well as diet and body mass index, levels of metabolites of DEHP, a phthalate commonly found in processed foods, were associated with higher age-, sex-, and height-standardized BP. For each log unit (roughly 3-fold) increase in DEHP metabolites, a 0.041 SD unit increase in systolic BP z-score was identified (P = .047). Metabolites of low molecular weight phthalates commonly found in cosmetics and personal care products were not associated with BP. Phthalate metabolites were not associated with triglyceride levels, high-density lipoprotein level, or prehypertension. Dietary phthalate exposure is associated with higher systolic BP in children and adolescents. Further work is needed to confirm these associations, as well as to evaluate opportunities for intervention.