Frequency-specific, valveless flow control in insect-mimetic microfluidic devices
Frequency-specific, valveless flow control in insect-mimetic microfluidic devices
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DOI：
10.1088/1748-3190/abe4bc
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发表时间：
2021-05-01
影响因子：
3.4
通讯作者：
Staples, Anne E.
中科院分区：
文献类型：
--
作者：
Chatterjee, Krishnashis;Graybill, Philip M.;Staples, Anne E.
廉价、便携的单芯片实验室设备将给环境监测和全球健康等领域带来革命性的变化，但目前的微流控芯片与广泛的芯片外硬件捆绑在一起。然而，昆虫是自给自足的，并熟练地使用在很大程度上未被探索的方法在微尺度上操纵液体。我们制造了一系列微流控设备，模拟了同步辐射成像观察到的昆虫呼吸运动学的关键特征，包括对单个波动的压力信号做出反应的多个呼吸道的部分坍塌。在一个单通道装置中，流量和方向可以单独由驱动频率控制，而不需要使用内部阀门。此外，我们制造了多通道芯片，其单个通道对单个全局激励频率有选择地响应(开启或关闭可变的、频率相关的流速)。我们的结果表明，仿昆虫设计有可能大幅降低微流控芯片的驱动开销，昆虫呼吸系统可能与阻抗失配泵具有相同的特征。
Inexpensive, portable lab-on-a-chip devices would revolutionize fields like environmental monitoring and global health, but current microfluidic chips are tethered to extensive off-chip hardware. Insects, however, are self-contained and expertly manipulate fluids at the microscale using largely unexplored methods. We fabricated a series of microfluidic devices that mimic key features of insect respiratory kinematics observed by synchrotron-radiation imaging, including the collapse of portions of multiple respiratory tracts in response to a single fluctuating pressure signal. In one single-channel device, the flow rate and direction could be controlled by the actuation frequency alone, without the use of internal valves. Additionally, we fabricated multichannel chips whose individual channels responded selectively (on with a variable, frequency-dependent flow rate, or off) to a single, global actuation frequency. Our results demonstrate that insect-mimetic designs have the potential to drastically reduce the actuation overhead for microfluidic chips, and that insect respiratory systems may share features with impedance-mismatch pumps.