Prognostic significance of tissue factor in pancreatic ductal adenocarcinoma
Prognostic significance of tissue factor in pancreatic ductal adenocarcinoma
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DOI：
10.1158/1078-0432.ccr-04-0866
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发表时间：
2005-04-01
影响因子：
11.5
通讯作者：
Hirohashi, S
中科院分区：
文献类型：
--
作者：
Nitori, N;Ino, Y;Hirohashi, S
组织因子（TF）是一种跨膜糖蛋白，在血液凝固和细胞内信号传导途径中发挥作用，也被认为是调节癌细胞的生物学行为。为探讨胰腺导管腺癌组织中TF表达的临床病理意义，采用免疫组化方法检测了113例胰腺导管腺癌手术切除标本中TF的表达。根据肿瘤细胞免疫阳性的发生率，将患者分为“阴性TF（0%）”、弱TF（
Tissue factor (TF) is a transmembrane glycoprotein that plays roles in the blood coagulation and intracellular signaling pathways, and has also been suggested to modulate the biological behavior of cancer cells. In order to examine the clinicopathologic significance of TF expression in pancreatic ductal adenocarcinoma, TF expression was determined by immunohistochemistry using a newly raised anti-TF monoclonal antibody in 113 patients who had undergone surgical resection of pancreatic ductal adenocarcinoma. According to the incidence of tumor cell immunopositivity, patients were divided into "negative TF (0%), "weak TF (