Hour-specific nomogram for transcutaneous Bilirubin in newborns in Myanmar
Hour-specific nomogram for transcutaneous Bilirubin in newborns in Myanmar
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DOI：
10.1111/ped.14251
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发表时间：
2020-09-14
影响因子：
1.4
通讯作者：
Kusaka, Takashi
中科院分区：
文献类型：
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作者：
Yasuda, Saneyuki;Suzuki, Hiromi;Kusaka, Takashi
背景 新生儿高胆红素血症是缅甸的一个重要健康问题，核黄疸的发生率也高于发达国家。迫切需要早期检测和治疗高胆红素血症的非侵入性方法。在这项研究中，我们使用经皮胆红素 (TcB) 测量来开发特定小时的 TcB 列线图，以有效管理缅甸新生儿的高胆红素血症。方法采用经皮胆红素测定仪对缅甸仰光中央妇女医院出生的新生儿在出生后72 h内每天测定3次胆红素水平。根据数据创建了特定于小时的 TcB 列线图。结果 参与者为仰光中央妇女医院出生的 512 名婴儿（287 名男孩，225 名女孩）。平均 (+/- SD) 胎龄为 38.4 +/- 1.2 周；出生体重为 3078 +/- 412 克。总共获得了 3,039 个图，并使用出生后 0-72 小时的平滑百分位数曲线（第 97.5 个、第 50 个百分位数和第 2.5 个百分位数）创建了 TcB 列线图。结论 成功创建了针对缅甸新生儿高胆红素血症的小时特异性 TcB 列线图。
Background Neonatal hyperbilirubinemia is a significant health problem in Myanmar, and the rate of kernicterus is also higher than in developed countries. Non-invasive methods for early detection and treatment of hyperbilirubinemia are urgently needed. In this study, we used transcutaneous bilirubin (TcB) measurements to develop an hour-specific TcB nomogram for the effective management of hyperbilirubinemia in Myanmar newborns. Methods The bilirubin levels of neonates born in Central Women Hospital in Yangon, Myanmar were measured three times a day within 72 h after birth using a transcutaneous bilirubinometer. An hour-specific TcB nomogram was created based on the data. Results Participants were 512 infants (287 boys, 225 girls) born in Central Women's Hospital in Yangon. The mean (+/- SD) gestational age was 38.4 +/- 1.2 weeks; birthweight was 3078 +/- 412 g. A total of 3,039 plots were obtained, and the TcB nomogram was created with smoothed percentile curves (97.5th, 50th, and 2.5th percentiles) for 0-72 h after birth. Conclusions An hour-specific TcB nomogram was successfully created to manage hyperbilirubinemia in Myanmar newborns.