DIETARY SELF-SELECTION AND THE ZUCKER RAT
DIETARY SELF-SELECTION AND THE ZUCKER RAT
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DOI：
10.1093/jn/112.4.796
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发表时间：
1982-01-01
影响因子：
4.2
通讯作者：
STERN, JS
中科院分区：
文献类型：
--
作者：
CASTONGUAY, TW;HARTMAN, WJ;STERN, JS
蛋白沉积受损可能是促进肥胖Zucker大鼠贪食的关键因素。研究了成年、雄性、遗传肥胖（fa/fa）和瘦（fa/ -） Zucker大鼠的选择模式，以确定肥胖大鼠是否会选择蛋白质含量高于瘦仔鼠的饮食。给大鼠随意提供3种常量营养素来源，并允许其自行配制日粮，为期9天。3种膳食为：维生素+矿物质补充碳水化合物来源（玉米淀粉），维生素+矿物质补充蛋白质来源（酪蛋白）和市售玉米油。肥胖的老鼠比瘦的同伴多摄入43%的卡路里。肥胖大鼠选择的饮食中，蛋白质占总热量摄入的12%，碳水化合物占24%，脂肪占64%。瘦老鼠选择的饮食中，蛋白质占总热量摄入的33%，碳水化合物占37%，脂肪占30%。这些选择数据不符合假设的重要性，即膳食蛋白质的作用及其与瘦体重的结合，作为一种促进暴饮暴食的刺激，遗传学肥胖的Zucker大鼠证明了这一点。
Impaired protein deposition may be a critical factor promoting the hyperphagia of the obese Zucker rat. The selection patterns of adult, male, genetically obese (fa/fa) and lean (Fa/-) Zucker rats were studied to determine if obese rats would select a diet that was higher in protein than the diet selected by lean littermates. Rats were provided ad lib access to 3 macronutrient sources and were allowed to compose their own diets for 9 days. The 3 dietary items were: a vitamin + mineral-supplemented carbohydrate source (cornstarch), a vitamin + mineral-supplemented protein source (casein) and commercially available corn oil. Obese rats ate 43% more calories than lean littermates. Obese rats selected a diet that provided 12% of their total caloric intake as protein, 24% as carbohydrate and 64% as fat. Lean rats selected a diet that provided 33% of their total caloric intake as protein, 37% as carbohydrate and 30% as fat. These selection data are not consistent with the hypothesized importance of the role of dietary protein and its incorporation into lean body mass as a stimulus promoting the hyperphagia demonstrated by the genetically obese Zucker rat.