Reduced anterior cingulate glutarnatergic concentrations in childhood OCD and major depression versus healthy controls
Reduced anterior cingulate glutarnatergic concentrations in childhood OCD and major depression versus healthy controls
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DOI：
10.1097/01.chi.0000132812.44664.2d
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发表时间：
2004-09-01
影响因子：
13.3
通讯作者：
Moore, GJ
中科院分区：
文献类型：
--
作者：
Rosenberg, DR;Mirza, Y;Moore, GJ
目的：观察强迫症(OCD)伴重度抑郁障碍(MDD)患儿和正常对照儿童前扣带回谷氨酸能神经化学变化。方法：应用单体素质子磁共振波谱技术对14例10~19岁无强迫症的精神药物依赖型MDD儿童青少年、14例健康对照和20例7~19岁非抑郁、精神药物依赖型强迫症儿童患者的前扣带回皮质进行核磁共振波谱分析。结果：与对照组相比，强迫症患者和MDD患者的前扣带回谷氨酸含量均显著降低(分别为15.1%和18.7%)。强迫症患者和IVIDD患者的前扣带回谷氨酸浓度无显著差异。结论：扣带回前部谷氨酸能神经递质改变可能参与强迫症和MDD的发病机制。这些初步研究结果进一步表明，前扣带回谷氨酸减少并不能区分儿童强迫症患者和儿童MDD患者。
Objective: To examine in vivo glutamatergic neurochemical alterations in the anterior cingulate cortex of pediatric patients with obsessive-compulsive disorder (OCD) without major depressive disorder (MDD) versus pediatric patients with MDD without OCD and healthy controls. Method: Single-voxel proton magnetic resonance spectroscopic examinations of the anterior cingulate cortex were conducted in 14 psychotropic-nave children and adolescents with MDD without OCD, 10 to 19 years of age, 14 case-matched healthy controls, and 20 nondepressed, psychotropic-nafve pediatric patients with OCD 7 to 19 years of age. Results: Anterior cingulate glutamatergic concentrations were significantly reduced in both patients with OCD (15.1% decrease) and patients with MDD (18.7% decrease) compared with controls. Anterior cingulate glutamatergic concentrations did not differ significantly between patients with OCD and those with IVIDD. Conclusions: Altered anterior cingulate glutamatergic neurotransmission may be involved in the pathogenesis of OCD and MDD. These preliminary findings further suggest that reduced anterior cingulate glutamate does not differentiate pediatric patients with OCD from pediatric patients with MDD.