No association between prostate apoptosis response 4 gene (PAWR) in schizophrenia and mood disorders in a japanese population
No association between prostate apoptosis response 4 gene (PAWR) in schizophrenia and mood disorders in a japanese population
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DOI：
10.1002/ajmg.b.30634
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发表时间：
2008-06
期刊：
影响因子：
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通讯作者：
T. Kishi;M. Ikeda;T. Kitajima;Tatsuyo Suzuki;Y. Yamanouchi;Y. Kinoshita;K. Kawashima;N. Ozaki;N. Iwata
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文献类型：
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作者：
T. Kishi;M. Ikeda;T. Kitajima;Tatsuyo Suzuki;Y. Yamanouchi;Y. Kinoshita;K. Kawashima;N. Ozaki;N. Iwata
多巴胺D2受体（D2R）改变被认为是严重精神病的易感因素。最近的研究表明，一种新的细胞内蛋白，前列腺凋亡反应4 (Par‐4)，在D2R信号传导中起关键作用。我们在日本人群（精神分裂症：556例，双相情感障碍（BP）： 150例，重度抑郁症（MDD）： 312例，对照466例）中进行了Par‐4基因（PAWR）与精神分裂症和情绪障碍之间的遗传关联分析。应用推荐的“基于基因的”关联分析，我们从HapMap数据库中选择了5个标记pawar的snp。未发现与精神分裂症、重度抑郁症或BP有显著关联。在基因型分析中，我们发现一个标记SNP与BP显著相关（P = 0.0396）；然而，这可能是由于多次测试导致的I型错误（SNPSpD校正后P = 0.158）。考虑到我们的样本和策略的大小，我们的结果表明，在日本人群中，PAWR在精神分裂症或情绪障碍中并不起主要作用。©2007 Wiley‐Liss, Inc。
Altered dopamine D2 receptor (D2R) is hypothesized to be a susceptibility factor for major psychosis. Recent studies showed that a new intracellular protein, prostate apoptosis response 4 (Par‐4), plays a critical role in D2R signaling. We conducted a genetic association analysis between Par‐4 gene (PAWR) and schizophrenia and mood disorders in a Japanese population (schizophrenia: 556 cases, bipolar disorder (BP): 150 cases, major depressive disorder (MDD): 312 cases and 466 controls). Applying the recommended ‘gene‐based’ association analysis, we selected five tagging SNPs in PAWR from the HapMap database. No significant association was obtained found with schizophrenia or MDD or BP. We found a significant association of one tagging SNP with BP in a genotype‐wise analysis (P = 0.0396); however, this might be resulted from type I error due to multiple testing (P = 0.158 after SNPSpD correction). Considering the size of our sample and strategy, our results suggest that the PAWR does not play a major role in schizophrenia or mood disorders in the Japanese population. © 2007 Wiley‐Liss, Inc.