HAPTEN-SPECIFIC T-CELL RESPONSES TO 4-HYDROXY-3-NITROPHENYL ACETYL .5. ROLE OF IDIOTYPES IN THE SUPPRESSOR PATHWAY
HAPTEN-SPECIFIC T-CELL RESPONSES TO 4-HYDROXY-3-NITROPHENYL ACETYL .5. ROLE OF IDIOTYPES IN THE SUPPRESSOR PATHWAY
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DOI：
10.1084/jem.152.1.161
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发表时间：
1980-01-01
影响因子：
15.3
通讯作者：
DORF, ME
中科院分区：
文献类型：
--
作者：
WEINBERGER, JZ;GERMAIN, RN;DORF, ME
4-Hydroxy-3-nitrophenyl (NP) derivatized syngeneic spleen cells [mouse] injected i.v. stimulate maturation of an antigen-binding, idiotype-bearing induction-phase suppressor cell population, as well as an idiotype-binding anti-idiotype-bearing effector-phase suppressor cell population. Both cell types are present simultaneously in the spleen cell population 7 days after their induction. The cell population with antigen-binding properties can, in the presence of NP-derivatized syngeneic cells, induce a population of effector suppressor cells. The precursors of the effector suppressor population are not sensitive to concentrations of cyclophosphamide which prevented the generation of induction phase suppressor cells. These data support the theory of network regulation of immune suppression.
