EFFECT OF PMSG ON FOLLICULAR ATRESIA IN THE IMMATURE RAT OVARY
EFFECT OF PMSG ON FOLLICULAR ATRESIA IN THE IMMATURE RAT OVARY
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DOI：
10.1530/jrf.0.0590267
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发表时间：
1980-01-01
期刊：
影响因子：
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通讯作者：
TSAFRIRI, A
中科院分区：
文献类型：
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作者：
BRAW, RH;TSAFRIRI, A
对26日龄大鼠给予PMSG [孕马血清促性腺激素]并未增加窦前（4型）和窦（5型和6型）卵泡的总数（非闭锁和闭锁），但改变了非闭锁和闭锁卵泡之间的比例。PMSG给药后12 h，仅7%的5型卵泡闭锁，未观察到6型闭锁卵泡，相比之下，生理盐水处理的对照组分别有42和62%的闭锁卵泡。PMSG没有降低腔前（4型）卵泡闭锁的百分比。给药后12 h，窦状卵泡（5型和6型）的固缩指数急剧下降。PMSG显然通过拯救闭锁的5型和6型卵泡并使它们达到排卵而引起大鼠超数排卵。
PMSG [pregnant mare serum gonadotropin] administration to 26 day old rats did not increase the total number (non-atretic and atretic) of preantral (Type 4) and antral (Types 5 and 6) follicles but changed the proportion between non-atretic and atretic follicles. By 12 h after PMSG administration only 7% of Type 5 follicles were atretic, and no atretic follicles of Type 6 were observed, as compared to 42 and 62% atretic follicles, respectively, in the saline-treated controls. PMSG did not decrease the percentage of atresia in preantral (Type 4) follicles. The treatment was associated with a sharp fall by 12 h in the pyknotic index of antral (Types 5 and 6) follicles. PMSG apparently causes superovulation in the rat by rescuing follicles of Types 5 and 6 from atresia and allowing them to reach ovulation.