Cochlioquinone derivatives produced by coculture of endophytes, Clonostachys rosea and Nectria pseudotrichia
Cochlioquinone derivatives produced by coculture of endophytes, Clonostachys rosea and Nectria pseudotrichia
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DOI：
10.1016/j.fitote.2021.105056
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发表时间：
2021-10-13
期刊：
影响因子：
3.4
通讯作者：
Shiono, Yoshihito
中科院分区：
文献类型：
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作者：
Sofian, Ferry Ferdiansyah;Suzuki, Takuma;Shiono, Yoshihito
从两种红树林真菌Clonostachys rosea B5-2和Nectria pseudotrichia B69-1的混合培养物中分离得到3个新的部分萜类衍生物：呋喃可可醌（1）和呋喃可可醌（2），以及nec-trianolin D（3），以及2个已知的生物遗传学相关化合物4和5。根据高分辨质谱和核磁共振数据推测了化合物1-3的结构。化合物1-5对人早幼粒细胞白血病（HL 60）细胞表现出细胞毒性，IC 50值为0.47 - 10.16 μ M。
Three new meroterpenoid derivatives, furanocochlioquinol (1) and furanocochlioquinone (2), as well as nec-trianolin D (3), together with two known biogenetically related compounds 4 and 5 were isolated from a mixed culture of two mangrove-derived fungi, Clonostachys rosea B5-2 and Nectria pseudotrichia B69-1. The structures of 1-3 were deduced based on the interpretation of HRMS and NMR data. Compounds 1-5 exhibited cytotoxicity against human promyelocytic leukemia (HL60) cells with IC50 values ranging from 0.47 to 10.16 mu M.