Liver function tests and neuropsychologic impairment in substance abusers.
Liver function tests and neuropsychologic impairment in substance abusers.
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药物滥用者的肝功能测试和神经心理损伤。
DOI：
10.1016/0306-4603(91)90039-k
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发表时间：
1991
影响因子：
4.4
通讯作者：
Beattie,MC
中科院分区：
文献类型：
--
作者：
Richardson,ED;Malloy,PF;Longabaugh,R;Williams,J;Noel,N;Beattie,MC
在治疗的急性期，酒精中毒者的残余神经心理功能障碍和肝功能的细微变化之间的关系进行了研究。与GGT正常或轻度升高的酗酒者相比，表现出肝酶γ-谷氨酰转移酶（GGT）极端升高的非酒精性酗酒者在视觉感知和概念能力的任务中受到更大的损害。急性肝功能障碍和残余神经心理损害之间的关系似乎与年龄和饮酒模式无关。这些研究结果的影响有关的治疗计划和酗酒者的预后进行了讨论。
The relationship between residual neuropsychologic dysfunction in alcoholics and subtle changes in liver function during acute phases of treatment was examined. Noncirrhotic alcoholics who exhibited extreme elevations in the liver enzyme gamma-glutamyl transferase (GGT) were found to have greater impairments in tasks of visuoperceptual and conceptual abilities when compared to alcoholics with normal or only mild elevations in GGT. The relationship between acute liver dysfunction and residual neuropsychologic impairment appeared to be independent of age and patterns of drinking. The implications of these findings in relation to treatment planning and prognosis of alcoholics are discussed.