Longitudinal quantitative MRI in multiple system atrophy and progressive supranuclear palsy
Longitudinal quantitative MRI in multiple system atrophy and progressive supranuclear palsy
复制标题
DOI：
10.1016/j.parkreldis.2013.10.002
复制
发表时间：
2014-02-01
影响因子：
4.1
通讯作者：
Mikulis, David J.
中科院分区：
文献类型：
--
作者：
Reginold, William;Lang, Anthony E.;Mikulis, David J.
目的：MRI已被用于帕金森综合征，以评估萎缩，组织水扩散率，矿物质沉积，但通常在一个单一的时间点。然而，多系统萎缩（MSA）和进行性核上性麻痹（PSP）是进行性疾病。本研究评估纵向MRI的价值，在表征的时间过程中的退行性processe.Methods：两个系列的MRI（平均23个月）进行了回顾性分析，在12 MSA，6 PSP，和18年龄和性别匹配的对照。评估包括选定的横截面积，区域表观扩散系数（ADC）和梯度回波（GRE）强度比的侧脑室，尾状核，壳核，小脑中脚，脑桥脑和midbrain.Results：在后续成像，有一个更大的ADC增加壳核PSP随着时间的推移相比，对照组（p = 0.02）。与对照组相比，MSA组脑桥随着时间的推移体积损失更大（p = 0.002）。在MSA中，小脑中脚ADC的变化与运动症状的严重程度根据统一帕金森病评定量表第三部分（p = 0.005）。结论：证据进行性神经变性可以观察到在MSA和PSP在两年内，包括增加壳核ADC的PSP和桥脑萎缩的MSA的MRI。(C)2013由Elsevier Ltd.出版
Objective: MRI has been used in parkinsonism to assess atrophy, tissue water diffusivity, and mineral deposition but usually at a single time-point. However, multiple system atrophy (MSA) and progressive supranudear palsy (PSP) are progressive diseases. This study assessed the value of longitudinal MRI in characterizing the time course of the degenerative process.Methods: Two serial MRIs (mean 23 months apart) were retrospectively analyzed in 12 MSA, 6 PSP, and 18 age and sex matched controls. Assessment included selected cross-sectional areas, regional apparent diffusion coefficient (ADC) and gradient echo (GRE) intensity ratios of the lateral ventricles, caudate, putamen, middle cerebellar peduncle, pons and midbrain.Results: On follow-up imaging, there was a larger ADC increase in the putamen in PSP over time compared to controls (p = 0.02). In MSA there was greater volume loss in the pons over time compared to controls (p = 0.002). In MSA the changes in middle cerebellar peduncle ADC were correlated with motor symptom severity according to the Unified Parkinson's Disease Rating Scale Part III (p = 0.005).Conclusions: Evidence of progressive neurodegeneration can be observed on MRI in MSA and PSP within two years consisting of increasing putaminal ADC in PSP and pontine atrophy in MSA. (C) 2013 Published by Elsevier Ltd.