Conformation of permethylated cyclodextrins and the host-guest geometry of their inclusion complexes
Conformation of permethylated cyclodextrins and the host-guest geometry of their inclusion complexes
复制标题
全甲基化环糊精的构象及其包合物的主客体几何形状
DOI：
10.1007/bf00656762
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
F. Hirayama
中科院分区：
文献类型：
--
作者：
K. Harata;K. Uekama;M. Otagiri;F. Hirayama
根据三种全甲基化α-环糊精和两种全甲基化β-环糊精包合物的X-射线衍射数据，研究了全甲基化环糊精的大环构象及其包合物的几何构型。由于甲基的空间位阻和不能形成分子内氢键，主体大环明显扭曲。客体分子被包含在主体空腔内，但它们的位置和取向与相应的环糊精复合物中的位置和取向完全不同。
Macrocylic conformation of permethylated cyclodextrins and the geometry of their inclusion complexes were examined on the basis of the X-ray data of three permethylated α-cyclodextrin complexes and two permethylated β-cyclodextrin complexes. The host macrocyclic ring is remarkably distorted owing to steric hindrance involving the methyl groups and the inability to form intramolecular hydrogen bonds. The guest molecules are included within the host cavity, but their position and orientation are quite different from those found in the corresponding cyclodextrin complexes.